Evidence map›Paper›PMID 40054522›Full record

ArticleJournal of global antimicrobial resistance2025

Detection of a genetically related carbapenemase-producing Escherichia coli ST167 in clinical and environmental isolates: Evidence for clonal spread of carbapenemase-producing Enterobacteriaceae in humans and the environment in Iowa, United States.

Hanseob Shin, David M Cwiertny, Megan J Nelson, Ryan T Jepson, Michael A Pentella, Darrin A Thompson

Abstract read
In one paragraph

Article in Journal of global antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Evidence of transmission and dissemination of diverseApplied and environmental microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hanseob ShinCenter for Health Effects of Environmental Contamination, University of Iowa, Iowa City, IA, United States; State Hygienic Laboratory, University of Iowa, Coralville, IA, United States. Electronic address: hanshin@uiowa.edu.
David M CwiertnyCenter for Health Effects of Environmental Contamination, University of Iowa, Iowa City, IA, United States; Department of Civil and Environmental Engineering, University of Iowa, Iowa City, IA United States; Department of Chemistry, University of Iowa, Iowa City, IA, United States.
Megan J NelsonState Hygienic Laboratory, University of Iowa, Coralville, IA, United States.
Ryan T JepsonState Hygienic Laboratory, University of Iowa, Coralville, IA, United States.
Michael A PentellaState Hygienic Laboratory, University of Iowa, Coralville, IA, United States.
Darrin A ThompsonCenter for Health Effects of Environmental Contamination, University of Iowa, Iowa City, IA, United States; Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

backgroundCarbapenemase-producing Enterobacteriaceae (CPE) are listed by the World Health Organization as one of the critical priority pathogens needing urgent attention to address global resistance to antimicrobials. Thus, the transmission and epidemiology of CPEs need to be studied via One Health perspectives.

methodsAn environmental CPE, referred to as BO1, was isolated from a creek in Northwest Iowa using a Colilert system (IDEXX, Westbrook, ME, USA). The presence of carbapenemase was examined using the modified carbapenem inactivation test, and then phenotypic resistance was determined using a Sensititre Complete Automated AST System (Thermo Fisher Scientific, Roskilde, Denmark). Whole-genome sequencing was performed and analysed to compare with clinical CPEs.

resultsBO1, carrying bla

conclusionsThe occurrence of BO1 was temporally and spatially close to that of one clinical strain, IA0018, implying the clonal spread of CPEs among humans and the environment, although the source and directionality of this spread remains unknown. This report illustrates the need for the strict control of CPEs in health care facilities and continuous surveillance within clinical and environmental settings to trace and prevent CPE transmission.

Indexed as

Bacterial Proteinsbeta-LactamasesCarbapenem-Resistant EnterobacteriaceaeEnvironmental MicrobiologyEscherichia coliEscherichia coli InfectionsAnti-Bacterial AgentsDrug Resistance, Multiple, BacterialHumansIowaMicrobial Sensitivity TestsWhole Genome SequencingAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasescarbapenemase

Identifiers

PMID40054522
PMCPMC12513237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.