ArticleCell2025
Sampling representational plasticity of simple imagined movements across days enables long-term neuroprosthetic control.
Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Simultaneous speech and gesture decoding for multimodal communication in paralysis.Nature neuroscience · 2026Article
- A neural architecture for imagined and overt speech motor dynamics.Nature neuroscience · 2026Article
- Assistive algorithms influence neural representations in motor brain-computer interfaces.Nature communications · 2026Article
- Optimal Size of Electrocorticography Grids for Classification of Hand Movements.Neuroinformatics · 2026Article
- Article
- Injectable Antifouling Adhesive Hydrogel Enables Robust Neural Interfaces for Stable ECoG Recording.Advanced healthcare materials · 2026Article
- Learning-related population dynamics in right and left dorsal premotor cortex during typing skill acquisition.bioRxiv : the preprint server for biology · 2026Article
- Concurrent control of natural and robotic limbs through a tactile-encoded brain-computer interface.Nature communications · 2026Article
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- Application Mechanisms and Clinical Prospects of Brain-Computer Interface Technology in Radiation-Induced Brain Injury.Cellular and molecular neurobiology · 2026Review
- Decoupling simultaneous motor imagination and execution via orthogonal ECoG neural representations.Nature communications · 2026Article
- Decoding intended speech with an intracortical brain-computer interface in a person with long-standing anarthria and locked-in syndrome.Cell reports · 2026Article
- Multi-Channel Neural Interface for Neural Recording and Neuromodulation.Small methods · 2026Review
- Chronically Stable, High-Resolution Micro-Electrocorticographic Brain-Computer Interfaces for Real-Time Motor Decoding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Longitudinal study of gesture decoding in a clinical trial participant with ALS.medRxiv : the preprint server for health sciences · 2025Article
- Implications of shared motor and perceptual activations on the sensorimotor cortex for neuroprosthetic decoding.Journal of neural engineering · 2025Article
- Metaplasticity and continual learning: mechanisms subserving brain computer interface proficiency.Journal of neural engineering · 2025Article
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Abstract
The nervous system needs to balance the stability of neural representations with plasticity. It is unclear what the representational stability of simple well-rehearsed actions is, particularly in humans, and their adaptability to new contexts. Using an electrocorticography brain-computer interface (BCI) in tetraplegic participants, we found that the low-dimensional manifold and relative representational distances for a repertoire of simple imagined movements were remarkably stable. The manifold's absolute location, however, demonstrated constrained day-to-day drift. Strikingly, neural statistics, especially variance, could be flexibly regulated to increase representational distances during BCI control without somatotopic changes. Discernability strengthened with practice and was BCI-specific, demonstrating contextual specificity. Sampling representational plasticity and drift across days subsequently uncovered a meta-representational structure with generalizable decision boundaries for the repertoire; this allowed long-term neuroprosthetic control of a robotic arm and hand for reaching and grasping. Our study offers insights into mesoscale representational statistics that also enable long-term complex neuroprosthetic control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.