Evidence map›Paper›PMID 40054301›Full record

ArticleResearch in developmental disabilities2025

Concurrent validity in language and motor domains on the Vineland-3 and Mullen Scales of Early Learning in young children with Down syndrome.

Chelsea La Valle, Sophie Hurewitz, McKena Geiger, Katherine Pawlowski, Nicole Baumer, Carol L Wilkinson

Abstract readValidation Study
In one paragraph

Article in Research in developmental disabilities, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chelsea La ValleDown Syndrome Program, Division of Developmental Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: downsyndrome.research@childrens.harvard.edu.
Sophie HurewitzLaboratories of Cognitive Neuroscience, Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; Down Syndrome Program, Division of Developmental Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
McKena GeigerLaboratories of Cognitive Neuroscience, Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Katherine PawlowskiDown Syndrome Program, Division of Developmental Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Nicole BaumerDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; Down Syndrome Program, Division of Developmental Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Carol L WilkinsonLaboratories of Cognitive Neuroscience, Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Neurobehavioral Research on Infants at Risk for SLI and AutismR01DC010290 · NIDCD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NELSON, CHARLES ALEXANDER, TAGER-FLUSBERG, HELEN · 2009 to 2020
$7.5M
Neural Markers of Language Development in Fragile X Syndrome and Autism Spectrum DisorderK23DC017983 · NIDCD · BOSTON CHILDREN'S HOSPITAL · PI WILKINSON, CAROL LEE · 2020 to 2024
$859k
Molecular mechanisms of aging in the intrinsic laryngeal musclesR03DC007983 · NIDCD · UNIVERSITY OF KENTUCKY · PI MCMULLEN, COLLEEN A · 2006 to 2009
$249k
NICHD NIH HHS P50 HD105351NIDCD NIH HHS K23 DC017983NIDCD NIH HHS R01 DC010290NIDCD NIH HHS R03 DC007983
6 · The paper itself

Abstract

backgroundObtaining information about individual's abilities in specific areas of development can be used to monitor early developmental progress in young children with Down syndrome (DS). Two commonly used measures which assess specific areas of development are the Mullen Scales of Early Learning (MSEL) and the Vineland Adaptive Behavior Scales-3rd Edition (VABS-3 parent interview). In DS, previous work found a positive association and moderate agreement between overall composite scores of these two measures. No study has explored the comparability of overlapping domains between the MSEL and VABS-3 parent interview in young children with DS.

aimThis study examined the concurrent validity between overlapping language and motor domains from two sources of information, parent report (VABS-3 interview) and direct assessment (MSEL) in young children with DS. METHODS AND PROCEDURES: Twenty-three young children with DS (14 males; mean age = 34.52, SD = 10.12, 13-48 months) completed the MSEL, which was administered by a trained examiner. Parents completed the VABS-3 interview remotely. Overlapping areas include language (receptive language; RL and expressive language; EL) and motor skills (fine motor; FM and gross motor; GM). OUTCOMES AND

resultsMedian age equivalent (AE) scores were similar when comparing overlapping domains. Across all four domains, MSEL and VABS-3 AE scores were strongly to very strongly positively associated (r CONCLUSIONS AND IMPLICATIONS: At a young age, the MSEL and VABS-3 parent interview provide a coherent portrait of age-level functioning in language and motor domains. Findings can help inform clinicians and researchers in selecting assessment tools to monitor developmental progress in growing hybrid in-person and telehealth care models. WHAT THIS PAPER ADDS?: Given the recent growth in hybrid clinical and research models that combine in-person and telemedicine visits, it is essential to better understand how direct in-person measures and remote/indirect parent report measures assessing language and motor skills relate to each other in young children with DS. This study evaluates concurrent validity using two different methods: parent report (Vineland Adaptive Behavior Scales-3rd Edition; VABS-3 interview) and direct assessment (Mullen Scales of Early Learning; MSEL), when measuring child developmental status in four overlapping domains (receptive language, expressive language, gross motor, and fine motor skills) in young children with DS. Findings suggest that for young children with DS, the VABS-3 parent interview provides similar age equivalent scores and developmental progress monitoring compared to the direct MSEL assessment.

Indexed as

Down SyndromeLanguage DevelopmentLanguage Development DisordersMotor SkillsChild DevelopmentChild, PreschoolFemaleHumansInfantMaleParentsReproducibility of ResultsDirect assessmentDown syndromeMullenParent reportVineland

Identifiers

PMID40054301
PMCPMC11955203

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