ArticleJournal of the American Chemical Society2025
Olefin Metathesis in Water: Speciation of a Leading Water-Soluble Catalyst Pinpoints Challenges and Opportunities for Chemical Biology.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Dynamic Self-Healing Polymer Architectures for High-Performance Flexible Sensing.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- On-oligonucleotide olefin metathesis in water.Nature communications · 2026Article
- Linker Engineering in Stapled Peptides for Enhanced Membrane Permeability: Screening and Optimization Strategies.International journal of molecular sciences · 2026Review
- De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis.Nature catalysis · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metathetical modification of biomolecules in aqueous environments holds great promise for advances at the interface of chemistry, biology, and medicine. However, rapid degradation of the metathesis catalysts necessitates their use in large stoichiometric excess, resulting in undesired side-reactions promoted by the ruthenium products. Although water is now known to play a central role in catalyst decomposition, the elusive nature of the intermediates has hampered insight into the pathways involved. We describe the detailed speciation in water of AquaMet (
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Registered trials
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