Evidence map›Paper›PMID 40053679›Full record

ArticleInflammatory bowel diseases2025

Small Bowel Motility Quantified by Cine MRI to Predict Longer-Term Response in Patients with Crohn's Disease Commencing Biological Therapy: The Motility Study.

Andrew A Plumb, Gordon Moran, Kashfia Chowdhury, Norin Ahmed, Sue Philpott, Tariq Ahmad, Stuart Bloom, Ailsa Hart, Ilan Jacobs, Alex Menys and 46 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammatory bowel diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors.

Andrew A PlumbDepartment of Radiology, University College London Hospitals, London, UK.ORCID 0000-0003-1322-5113
Gordon MoranQueen's Medical Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0002-8906-6908
Kashfia ChowdhuryComprehensive Clinical Trials Unit, University College London, London, UK.
Norin AhmedComprehensive Clinical Trials Unit, University College London, London, UK.
Sue PhilpottComprehensive Clinical Trials Unit, University College London, London, UK.
Tariq AhmadDepartment of Gastroenterology, Royal Devon and Exeter Hospital, Exeter, UK.
Stuart BloomDepartment of Gastroenterology, University College London Hospitals, London, UK.
Ailsa HartDepartment of Gastroenterology, St Mark's Hospital, London, UK.
Ilan JacobsPatient representative, London, UK.
Alex MenysMotilent, London, UK.
Peter MooneyDepartment of Gastroenterology, St James' Hospital, Leeds, UK.
Damian TolanDepartment of Radiology, St James' Hospital, Leeds, UK.
Simon TravisDepartment of Gastroenterology, Oxford Radcliffe Hospitals, Oxford, UK.ORCID 0000-0002-2690-4361
Anisha BhagwananiDepartment of Radiology, Frimley Health NHS Trust, Frimley, UK.
Gauraang BhatnagarMotilent, London, UK.
Darren BooneDepartment of Radiology, University College London Hospitals, London, UK.
James FranklinDepartment of Radiology, University Hospitals Dorset, Bournemouth, UK.
Anmol Gangi-BurtonDepartment of Radiology, Nottingham University Hospitals, Nottingham, UK.
Maira HameedDepartment of Radiology, University College London Hospitals, London, UK.
Emma HelbrenDepartment of Radiology, Hull University Teaching Hospitals NHS Trust, Hull, UK.
Faraz Hosseini-ArdehaliDepartment of Radiology, University College London Hospitals, London, UK.
Rachel HylandDepartment of Radiology, St James' Hospital, Leeds, UK.
Yakup KilicDepartment of Radiology, University College London Hospitals, London, UK.
Shankar KumarDepartment of Radiology, University College London Hospitals, London, UK.ORCID 0000-0002-5945-8791
Hannah LambieDepartment of Radiology, St James' Hospital, Leeds, UK.
Maryam MohsinDepartment of Radiology, St James' Hospital, Leeds, UK.
Anisha PatelDepartment of Radiology, Western General Hospital, Edinburgh, UK.
Safi RahmanDepartment of Radiology, St James' Hospital, Leeds, UK.
Naomi SakaiDepartment of Radiology, University College London Hospitals, London, UK.
Harbir SidhuDepartment of Radiology, University College London Hospitals, London, UK.
Elen ThomsonDepartment of Radiology, St James' Hospital, Leeds, UK.
Saiam AhmedComprehensive Clinical Trials Unit, University College London, London, UK.
Uday Bannur ChikkeragowdaDepartment of Radiology, Nottingham University Hospitals, Nottingham, UK.
Nina BarrattWessex Health Partners, Southampton, UK.
Teresita BeestonDepartment of Radiology, University College London Hospitals, London, UK.
Heather FitzkeCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Nicola GibbonsDepartment of Radiology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
Edmund GodfreyDepartment of Radiology, Addenbrookes Hospital, Cambridge, UK.
Arun GuptaDepartment of Radiology, St Mark's Hospital, London, UK.
Antony HigginsonDepartment of Radiology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
Elizabeth IsaacDepartment of Radiology, University College London Hospitals, London, UK.
Klaartje Bel KokDepartment of Gastroenterology, Barts Health NHS Trust, London, UK.
Sarah LanglandsDepartment of Gastroenterology, Frimley Health NHS Trust, UK.
Miles ParkesDepartment of Gastroenterology, Addenbrookes Hospital, Cambridge, UK.
Jaymin PatelDepartment of Radiology, St George's University Hospitals NHS Trust, London, UK.
Kamal PatelDepartment of Radiology, St George's University Hospitals NHS Trust, London, UK.
Kamini PatelDepartment of Radiology, Homerton Healthcare NHS Trust, London, UK.
Nishant PatodiDepartment of Gastroenterology, Royal Berkshire NHS Trust, Reading, UK.
Richard PollokDepartment of Gastroenterology, St George's University Hospitals NHS Trust, London, UK.
Robert PrzemiosoloDepartment of Gastroenterology, North Bristol NHS Trust, Bristol, UK.
Charlotte RobinsonDepartment of Radiology, Royal Berkshire NHS Trust, Reading, UK.
Nora ThouaDepartment of Gastroenterology, Homerton Healthcare NHS Trust, London, UK.
Anvi WadkeComprehensive Clinical Trials Unit, University College London, London, UK.
Steve HalliganCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Stuart A TaylorCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
MOTILITY study co-authors

Funding

National Institute for Health Research 14/201/16
6 · The paper itself

Abstract

backgroundSmall bowel Crohn's disease (SBCD) is increasingly treated with biological therapies. Predicting response or remission (RoR) for individual patients is difficult and complicates treatment strategy. We aimed to determine if motility magnetic resonance imaging (mMRI) is superior to CRP and fecal calprotectin (FC) for the prediction of RoR at 1 year in patients commencing biologics for SBCD.

methodsProspective, multicenter (n = 13) cohort study of patients with active non-stricturing SBCD requiring anti-TNFα or anti-IL-12/23 treatment. We measured mMRI and CRP at baseline and post-induction (visit 2: 12-30 weeks), and FC in a subset. RoR was assessed at 1 year using clinical and structural magnetic resonance enterography parameters. We compared sensitivity, specificity, and area under the receiver operating characteristic curve (ROC-AUC) of changes in mMRI and CRP to predict RoR at 1 year. Secondary outcomes compared mMRI with FC, and prediction of improved quality of life (QoL).

resultsEighty-six participants completed all assessments. Stable or improved mMRI at visit 2 was more sensitive than normalization of CRP for RoR (mMRI:71.0%, 95%CI 52.0-85.8; CRP:45.2%, 95%CI 27.3-64.0%, P = .008) but less specific (mMRI:30.9%, 95%CI 19.1-44.8; CRP:67.3%, 95%CI 53.3-79.3%, P < .001). There was no significant difference in ROC-AUC (mMRI:0.48; CRP:0.53, P = .65). Similar results were obtained for FC. None of mMRI, CRP, or FC predicted patient QoL at 1 year.

conclusionsAlthough improved mMRI is more sensitive than CRP and FC to predict RoR at 1 year, it is less specific. No factor predicted patient QoL. Motility MRI remains a marker of disease activity at given timepoints.

Indexed as

Biological TherapyCrohn DiseaseGastrointestinal MotilityIntestine, SmallMagnetic Resonance Imaging, CineAdultC-Reactive ProteinFecesFemaleFollow-Up StudiesHumansLeukocyte L1 Antigen ComplexMaleMiddle AgedPrognosisProspective StudiesC-Reactive ProteinLeukocyte L1 Antigen Complexbiologics (IBD)Crohn’s diseaseinflammatory bowel diseaseradiology/imagingsmall intestine

Identifiers

PMID40053679
PMCPMC12455588

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.