Evidence map›Paper›PMID 40053382›Full record

ReviewJournal of medicinal chemistry2025

An Amazing 30-Year Journey around the DABO Family: A Medicinal Chemistry Lesson on a Versatile Class of Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors.

Emanuele Fabbrizi, Vladimir V Chernyshov, Francesco Fiorentino, Gianluca Sbardella, Rino Ragno, Maxim Nawrozkij, Roman Ivanov, Dante Rotili, Antonello Mai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emanuele FabbriziDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Vladimir V ChernyshovSirius University of Science and Technology, Olympic Avenue, 1, 354340, Federal Territory of Sirius, Krasnodar Region Russian Federation.
Francesco FiorentinoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-3550-1860
Gianluca SbardellaDepartment of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084 Fisciano, SA, Italy.ORCID 0000-0003-0748-1145
Rino RagnoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-5399-975X
Maxim NawrozkijSirius University of Science and Technology, Olympic Avenue, 1, 354340, Federal Territory of Sirius, Krasnodar Region Russian Federation.
Roman IvanovSirius University of Science and Technology, Olympic Avenue, 1, 354340, Federal Territory of Sirius, Krasnodar Region Russian Federation.
Dante RotiliDepartment of Science, Roma Tre University of Rome, Viale Guglielmo Marconi 446, 00146 Rome, Italy.ORCID 0000-0002-8428-8763
Antonello MaiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-9176-2382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the emergence of AIDS, the non-nucleoside HIV-1 RT inhibitors (NNRTIs) have attracted the attention of scientists and clinicians due to their high potency and specificity combined with low toxicity. 3,4-Dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs) are a family of NNRTIs described since 1992, and the best members among

Indexed as

Anti-HIV AgentsHIV-1HIV Reverse TranscriptaseReverse Transcriptase InhibitorsChemistry, PharmaceuticalHumansPyrimidinesStructure-Activity RelationshipAnti-HIV AgentsHIV Reverse TranscriptasePyrimidinesreverse transcriptase, Human immunodeficiency virus 1Reverse Transcriptase Inhibitors

Identifiers

PMID40053382
PMCPMC11956011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.