Evidence map›Paper›PMID 40053361›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Bacterial estrogenesis without oxygen: Wood-Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere.

Po-Hsiang Wang, Tien-Yu Wu, Yi-Lung Chen, Ronnie G Gicana, Tzong-Huei Lee, Mei-Jou Chen, Tsun-Hsien Hsiao, Mei-Yeh Jade Lu, Yi-Li Lai, Tzi-Yuan Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Bacteria on steroids.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Po-Hsiang Wang *Graduate Institute of Environmental Engineering, National Central University, Taoyuan 320, Taiwan.ORCID 0000-0001-9900-0972
Tien-Yu Wu *Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan.
Yi-Lung ChenDepartment of Agricultural Chemistry, National Taiwan University, Taipei 106, Taiwan.
Ronnie G GicanaBiodiversity Research Center, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0001-8549-9215
Tzong-Huei LeeInstitute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan.
Mei-Jou ChenDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0002-2305-1105
Tsun-Hsien HsiaoSchool of Medicine, National Tsing Hua University, Hsinchu 300, Taiwan.ORCID 0000-0003-2002-2760
Mei-Yeh Jade LuBiodiversity Research Center, Academia Sinica, Taipei 115, Taiwan.
Yi-Li LaiBiodiversity Research Center, Academia Sinica, Taipei 115, Taiwan.
Tzi-Yuan WangBiodiversity Research Center, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0002-1562-0144
Jeng-Yi LiBiodiversity Research Center, Academia Sinica, Taipei 115, Taiwan.
Yin-Ru ChiangBiodiversity Research Center, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0001-6899-3166

Funding

Academia Sinica (AS) AS-CDA-110-L13National Science and Technology Council (NSTC) 110-2311-B-001-033-MY3
6 · The paper itself

Abstract

Androgen and estrogen, key sex hormones, were long thought to be exclusively produced by vertebrates. The O

Indexed as

EstrogensOxygenAnaerobiosisAnimalsAromataseMultigene FamilyTestosteroneAromataseEstrogensOxygenTestosteroneanaerobic microbiologyaromaticsC1 metabolismmethyltransferaseWood–Ljungdahl pathway

Identifiers

PMID40053361
PMCPMC11912376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.