Evidence map›Paper›PMID 40053249›Full record

ArticleIntensive care medicine experimental2025

Expiratory ventilation assistance versus pressure-controlled ventilation with ambient oxygen in a hemorrhagic trauma model: a prehospital rescue option?

Tomas Karlsson, Jenny Gustavsson, Katrin Wellfelt, Mattias Günther

Abstract read
In one paragraph

Article in Intensive care medicine experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Tomas KarlssonDepartment of Clinical Science and Education, Section of Anesthesiology and Intensive Care, Karolinska Institutet, Sjukhusbacken 10, 11883, Stockholm, Sweden. tomas.karlsson@ki.se.ORCID http://orcid.org/0000-0002-0894-7288
Jenny GustavssonDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Katrin WellfeltDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Mattias GüntherDepartment of Clinical Science and Education, Section of Anesthesiology and Intensive Care, Karolinska Institutet, Sjukhusbacken 10, 11883, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrehospital airway management is critical for maintaining oxygenation after severe trauma hemorrhage. In cases of semi-obstructed airways, intubation with an endotracheal tube may fail, whereas a 14 French intubating catheter may provide an alternative for ventilation. Expiratory ventilation assistance (EVA) through such a catheter could serve as a prehospital rescue option, particularly when oxygen supply is limited. This study evaluates whether EVA with ambient air is sufficient to maintain oxygenation and compares its effectiveness with pressure-controlled ventilation (PCV).

methodsTwenty-three anesthetized swines (mean weight 58.3 kg, SD 4.6) were subjected to 32% blood volume hemorrhage and allocated to either EVA (n = 11) or PCV (n = 12). Historical data were used in the control group. Three phases were studied: 15 min without intervention (emulating initial prehospital care), 30 min of whole blood resuscitation, and 15 min post-resuscitation. Parameters including oxygen delivery (DO

resultsEVA and PCV demonstrated similar effectiveness in maintaining indexed DO

conclusionBoth EVA and PCV effectively maintained oxygen delivery and sufficient oxygenation after trauma hemorrhage and whole blood resuscitation. Lower intratracheal pressures and reduced lactate accumulation with EVA suggest it may be a viable prehospital rescue method, especially in scenarios with limited oxygen supply. Further investigation is warranted to optimize its application.

Indexed as

Airway obstructionExpiratory ventilation assistancePorcine class III hemorrhageVentrainWhole blood resuscitation

Identifiers

PMID40053249
PMCPMC11889277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.