ArticleApplied biochemistry and biotechnology2025
Mesenchymal Stem Cell-Derived Exosome miR-153-3 Induced M2-Type Polarization of Macrophages to Improve the Healing Effect of Burn Wounds.
Article in Applied biochemistry and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Macrophage-MSCs Interplay in Orthodontic Bone Remodelling: Mechanics-Immunity-Stem Cell Axis.International dental journal · 2026Review
- The Potentials of Stem Cell-Derived Exosomal MicroRNAs in Ferroptosis Modulation: Molecular Insights into Hepatoprotection, Neuroprotection, Cardioprotection, Renoprotection and Pulmonoprotection.Stem cell reviews and reports · 2026Review
- Exosomes derived from bone marrow mesenchymal stem cells facilitate repair of radiation-Induced skin injury by attenuating inflammation and apoptosis.Scientific reports · 2026Article
- Research progress on functionalized stem cell therapy strategies in wound healing.Frontiers in cell and developmental biology · 2026Review
- Innovative Pathways in Burn Treatment: Exosomes and the New Era of Regenerative Medicine.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The healing process of wounds, as soft tissue injuries, is challenging. Bone marrow mesenchymal stem cells (BMSCs) and exosomes (Ex) they secrete are critical for skin wound healing. Paracrine signaling mechanisms appear to facilitate the therapeutic properties of BMSCs. However, BMSC therapy has not yet been extensively explored in terms of specific cellular interactions between macrophages and BMSCs. In this study, macrophage depletion had a substantial negative impact on the wound healing capabilities of BMSCs, highlighting macrophages' crucial role in facilitating wound healing processes mediated by BMSCs. BMSCs transferred to the wound site promoted M2 polarization and alleviated wound healing. The co-cultivation of BMSCs and macrophages resulted in an enhanced phenotypic polarization towards M2. A mechanistic explanation for this effect was found in BMSCs-Ex. Additionally, miR-153-3p, derived from BMSCs-Ex, was identified as a regulator of macrophage polarization via its targeting of KPNA5. Through the transfer of BMSCs-Ex-derived miR-153-3p, BMSCs are capable of promoting M2 polarization and can potentially facilitate wound healing.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.