Evidence map›Paper›PMID 40053180›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Acute onset anti-MAG neuropathy and paradoxical worsening to rituximab: a challenging case.

Emanuele Cassano, Rosa Iodice, Isabella Di Sarno, Roberta Bencivenga, Fiore Manganelli, Stefano Tozza

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Emanuele CassanoDepartment of Neuroscience, Reproductive and Odontostomatological Science, University of Naples Federico II, Via Sergio Pansini, 5, Naples, Italy.
Rosa IodiceDepartment of Neuroscience, Reproductive and Odontostomatological Science, University of Naples Federico II, Via Sergio Pansini, 5, Naples, Italy.
Isabella Di SarnoDepartment of Neuroscience, Reproductive and Odontostomatological Science, University of Naples Federico II, Via Sergio Pansini, 5, Naples, Italy.
Roberta BencivengaDepartment of Neuroscience, Reproductive and Odontostomatological Science, University of Naples Federico II, Via Sergio Pansini, 5, Naples, Italy.
Fiore Manganelli *Department of Neuroscience, Reproductive and Odontostomatological Science, University of Naples Federico II, Via Sergio Pansini, 5, Naples, Italy.
Stefano Tozza *Department of Neuroscience, Reproductive and Odontostomatological Science, University of Naples Federico II, Via Sergio Pansini, 5, Naples, Italy. stefano.tozza@unina.it.ORCID http://orcid.org/0000-0002-9672-4577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimAnti-myelin-associated glycoprotein (anti-MAG) neuropathy is typically a chronic, progressive, predominantly sensory distal and demyelinating neuropathy, with ataxia and postural tremor METHODS AND

resultsHerein we describe an atypical case of anti-MAG neuropathy, characterized by acute lower limb weakness and severe ataxia with difficulty in stance and walking, resembling a Guillain-Barrè Syndrome. The presence of disproportionate distal nerve conduction slowing, and an IgM k monoclonal component have arisen the suspect of anti-MAG neuropathy, confirmed by high titer anti-MAG antibody. Rituximab treatment was started, and patient experienced a dramatic clinical worsening which was rescued by Plasma Exchange.

interpretationWe described an atypical case of anti-MAG neuropathy that was challenging in diagnosis and therapeutic management.

Indexed as

Immunologic FactorsMyelin-Associated GlycoproteinPeripheral Nervous System DiseasesRituximabAutoantibodiesHumansNeural ConductionAutoantibodiesImmunologic FactorsMAG protein, humanMyelin-Associated GlycoproteinRituximabAcute onsetAnti-MAG neuropathyPlasma exchangeRituximab

Identifiers

PMID40053180

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