Evidence map›Paper›PMID 40053127›Full record

ArticleMolecular genetics and genomics : MGG2025

Prevalence and molecular spectrum of thalassemia in infertile population among different ethnic groups in Hainan Province, China.

Yongle Zhang, Jinyu Kang, Wenye Sun, Fei Sun, Ge Gao, Junhong Chen, Qi Li, Qiuling Jie, Yanlin Ma

Abstract read
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In one paragraph

Article in Molecular genetics and genomics : MGG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Identification of maternalAnnals of medicine · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yongle Zhang *Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Province & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570102, Hainan, China.
Jinyu Kang *Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Province & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570102, Hainan, China.
Wenye SunKey Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Province & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570102, Hainan, China.
Fei SunKey Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Province & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570102, Hainan, China.
Ge GaoKey Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Province & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570102, Hainan, China.
Junhong ChenKey Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Province & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570102, Hainan, China.
Qi LiKey Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Province & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570102, Hainan, China.
Qiuling JieKey Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Province & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570102, Hainan, China. jql990502727@hotmail.com.ORCID http://orcid.org/0000-0002-1338-0888
Yanlin MaKey Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education & Key Laboratory of Human Reproductive Medicine and Genetic Research of Hainan Province & Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 570102, Hainan, China. mayanlinma@hotmail.com.

Funding

Hainan Province Science and Technology project LCYX202301Hainan Province Science and Technology Project LCYX202102Hainan Province Science and Technology Project LCYX202203Major Science and Technology Project of Hainan Province ZDKJ2021037
6 · The paper itself

Abstract

Hainan is an area with high prevalence of thalassemia and complex genetic background. There are few studies on the prevalence and genotype of thalassemia in different ethnic groups of infertility patients in Hainan province. The aim of our study was to explore the prevalence and genotype of thalassemia among infertile individuals in Hainan Province. Thalassemia genotypes were determined using gap-PCR and PCR-RBD in 13,856 infertile individuals in our study. Among them, 3458 (24.96%) were diagnosed as thalassemia carriers. In Li ethnic group, 649 (75.12%) were diagnosed as thalassemia carriers, which significantly higher than Han (21.62%) and other ethnicities (22.09%). As the molecular spectrum of thalassemia, the most common α-thalassemia genotype among Han and other ethnicities was -α

Indexed as

alpha-Thalassemiabeta-ThalassemiaInfertilityThalassemiaAdultChinaEast Asian PeopleEthnicityFemaleGenotypeHumansMalePrevalenceYoung AdultEthnic groupsGenotypeHainan ProvinceInfertile populationThalassemia

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.