Evidence map›Paper›PMID 40053115›Full record

Trial reportJournal of bone and mineral metabolism2025

Quercetins efficacy on bone and inflammatory markers, body composition, and physical function in postmenopausal women.

Alyssa R Bailly, Garrett M Hester, Michaela G Alesi, Robert J Buresh, Yuri Feito, Christine M Mermier, Jeremy B Ducharme, Trisha A VanDusseldorp

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of bone and mineral metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05371340 (The Efficacy of Quercetin Supplementation on Bone Turnover Markers, Inflammatory Markers, Body Composition, and Physical Function in Post-Menopausal Women), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05371340 nacompletednot on this map

The Efficacy of Quercetin Supplementation on Bone Turnover Markers, Inflammatory Markers, Body Composition, and Physical Function in Post-Menopausal Women

TypeinterventionalSponsorKennesaw State UniversityRan2019 to 2020Enrolled33ConditionsOsteoporosis, PostmenopausalArmsQuercetin (500 mg), Placebo (500 mg)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Yerba Mate (Nutrients · 2025
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Alyssa R BaillyDepartment of Exercise Science and Sport Management, Kennesaw State University, 520 Parliament Garden Way NW, Kennesaw, Georgia, 30144, United States of America. abailly24@unm.edu.ORCID http://orcid.org/0000-0002-1800-3969
Garrett M HesterDepartment of Exercise Science and Sport Management, Kennesaw State University, 520 Parliament Garden Way NW, Kennesaw, Georgia, 30144, United States of America.
Michaela G AlesiDepartment of Exercise Science and Sport Management, Kennesaw State University, 520 Parliament Garden Way NW, Kennesaw, Georgia, 30144, United States of America.
Robert J BureshDepartment of Exercise Science and Sport Management, Kennesaw State University, 520 Parliament Garden Way NW, Kennesaw, Georgia, 30144, United States of America.
Yuri FeitoDepartment of Exercise Science and Sport Management, Kennesaw State University, 520 Parliament Garden Way NW, Kennesaw, Georgia, 30144, United States of America.
Christine M MermierDepartment of Health, Exercise, and Sports Sciences, University of New Mexico, 200 Cornell Dr, Albuquerque, NM, 87131, United States of America.
Jeremy B DucharmeDepartment of Health, Exercise, and Sports Sciences, University of New Mexico, 200 Cornell Dr, Albuquerque, NM, 87131, United States of America.
Trisha A VanDusseldorpDepartment of Exercise Science and Sport Management, Kennesaw State University, 520 Parliament Garden Way NW, Kennesaw, Georgia, 30144, United States of America.

Funding

Kennesaw State University Department of Exercise Science Research Enhancement Grant Program ES0765
6 · The paper itself

Abstract

introductionThis study aimed to investigate the effects of quercetin (a plant-based flavonoid) supplementation over 90 days on prominent bone turnover markers (BTMs), inflammatory markers, bone mineral density (BMD), body composition, and physical function in postmenopausal women. MATERIALS AND

methodsThirty-three healthy postmenopausal women were recruited to participate in a double-blind, placebo-controlled investigation. Participants were randomized into one of two supplement groups: (1) 500 mg of quercetin (QUE) once daily or (2) 500 mg of methylcellulose (placebo; PLB) once daily. Pre- and post-testing visits included assessments of BTMs (i.e., osteocalcin [OC], procollagen type I N-terminal propeptide [PINP], and type I collagen cross-linked C-terminal telopeptide [CTX]), inflammatory markers (i.e., interleukin [IL]-6, tumor necrosis factor-alpha [TNF-α], and C-reactive protein [CRP]), BMD measurements, body composition measurements, and physical function including timed up and go and handgrip strength.

resultsThe QUE group increased OC (p = 0.016; d = 0.89), PINP (p = 0.030; d = 0.64), and CTX (p = 0.023; d = 0.91) levels and decreased IL-6 (p = 0.045; d = 0.73) and TNF-α (p = 0.021; d = 0.90) levels compared to PLB. CRP (p = 0.448; d = 0.34), body composition (p > 0.05), and physical function (p > 0.05) remained unchanged.

conclusionThe results suggest that QUE may better assist in controlling a normal bone turnover cycle by mediating bone formation and decreasing pro-inflammatory cytokines. However, although within the accepted range, there was an increase in the bone resorption marker and therefore, it is unclear if QUE will protect against future bone loss. Nonetheless, additional research is necessary to evaluate the bone-conserving properties of QUE among postmenopausal women. CLINICAL TRAIL REGISTRATION: The ClinicalTrials.gov ID number: NCT05371340.

Indexed as

BiomarkersBody CompositionBone and BonesInflammationPostmenopauseQuercetinAgedBone DensityBone RemodelingDouble-Blind MethodFemaleHumansMiddle AgedBiomarkersQuercetinBone healthFlavonoidInflammationPostmenopausalQuercetin

Identifiers

PMID40053115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.