ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas2025
Prediction of maximum oxygen uptake over time in adults: analysis from the FRIEND registry.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Long-term impact of the COVID-19 pandemic on physical activity and estimated cardiorespiratory fitness in south American adults: a multi-country cross-sectional online survey.Archives of public health = Archives belges de sante publique · 2025Article
- Prediction of maximum oxygen uptake over time in adults: analysis from the FRIEND registry.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2025Article
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13 authors.
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Abstract
Maximum oxygen uptake (V̇O2max) equations from developed countries are inaccurate for developing countries. Accordingly, we aimed to develop equations to predict treadmill V̇O2max over time based on variables other than exercise test in adults from the USA and Brazil undergoing cardiopulmonary exercise testing (CPET). We analyzed data from 2,170 adults who underwent two CPETs (1,307 men; 20-85 years) from the USA (n=1,880) and Brazil (n=290) with a second test after 2.0±1.7 years on average. We fit linear mixed-effects models to develop equations using 90% of the sample, randomly selected. In the remaining 10% of the cohort, we used the coefficient of variation, intraclass correlation coefficient, and the Bland and Altman plots to cross-validate the optimal equation. Our best linear mixed model equation was as follows: V̇O2max (mLO2·kg-1·min-1) = 62.01 - (0.23×Ageyears) - (0.001×Age×Age) - (0.65×Body mass indexkg/m 2) + (5.47×Sexfemales=0; males=1) + (2.78×CountryBrazil=0; USA=1) - (0.68×Arterial hypertensionno=0; yes=1) - (0.45×Hyperlipidemiano=0; yes=1) - (2.02×Smokingno=0; yes=1) - (4.36×Insufficiently activeno=0; yes=1) - (1.67×Beta-blockersno=0; yes=1); R2=0.566. Our main equation was reliable at baseline according to Bland and Altman plot results (mean difference, 0.01 mLO2·kg-1·min-1: 95%CI, -13.94 to 13.98; P=0.966) and over time (0.44 mLO2·kg-1·min-1: 95%CI, -13.5 to 12.4; P=0.439). Demographic and anthropometric attributes, cardiovascular risk, and beta-blockers are valuable for predicting V̇O2max at baseline and over time. The developed equations may apply to countries with socioeconomic and demographic characteristics such as Brazil and the USA.
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