Evidence map›Paper›PMID 40052803›Full record

ArticlemBio2025

Novel type II toxin-antitoxin systems with VapD-like proteins.

Konstantin Gilep, Dmitry Bikmetov, Aleksandr Popov, Anastasiia Rusanova, Shunsuke Tagami, Svetlana Dubiley, Konstantin Severinov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Microorganisms · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Konstantin GilepCenter for Precision Genome Editing and Genetic Technologies for Biomedicine Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Dmitry BikmetovCenter for Precision Genome Editing and Genetic Technologies for Biomedicine Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0001-6788-9156
Aleksandr PopovRIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa, Japan.
Anastasiia RusanovaKoltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
Shunsuke TagamiRIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa, Japan.
Svetlana DubileyInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Konstantin SeverinovInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0001-9706-450X

Funding

Ministry of Science and Higher Education of the Russian Federation (Minobrnauki of Russia) 075-15-2019-1661RIKEN Junior Research Associate ProgramRussian Science Foundation (RSF) 24-14-00181
6 · The paper itself

Abstract

Type II toxin-antitoxin (TA) systems are widespread in prokaryotes. They consist of neighboring genes encoding two small proteins: a toxin that inhibits a critical cellular process and an antitoxin that binds to and neutralizes the toxin. The VapD nuclease and the VapX antitoxin comprise a type II TA system that contributes to the virulence of the human pathogen IMPORTANCE: Genes encoding virulence-associated protein D (VapD) homologs are found in many pathogens such as

Indexed as

AntitoxinsBacterial ProteinsBacterial ToxinsHaemophilus influenzaeToxin-Antitoxin SystemsCrystallography, X-RayModels, MolecularProtein ConformationAntitoxinsBacterial ProteinsBacterial ToxinsCas2evolutionSOS-responsetoxin-antitoxin systemsVapD

Identifiers

PMID40052803
PMCPMC11980593

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.