Evidence map›Paper›PMID 40052788›Full record

ArticleMicrobiology spectrum2025

Multi-omics analysis of the mechanism of alfalfa and wheat-induced rumen flatulence in Xizang sheep.

Jing Wu, Xiaoming Zhang, Khan Ayesha, Shahzad Khuram, Jianzhao Cui, Gaofu Wang, Zhaxi Yangzong, Mingyan Shi, Xunping Jiang, Long Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jing Wu *Institute of Animal Science, Xizang Academy of Agricultural and Animal Husbandry Science, Lhasa, Xizang, China.ORCID 0009-0001-9484-1403
Xiaoming Zhang *Institute of Animal Science, Xizang Academy of Agricultural and Animal Husbandry Science, Lhasa, Xizang, China.
Khan AyeshaSchool of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Shahzad KhuramInterdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad (CUI), Lahore, Pakistan.
Jianzhao CuiInstitute of Animal Science, Xizang Academy of Agricultural and Animal Husbandry Science, Lhasa, Xizang, China.
Gaofu WangChongqing Academy of Animal Science, Chongqing, China.
Zhaxi YangzongInstitute of Animal Science, Xizang Academy of Agricultural and Animal Husbandry Science, Lhasa, Xizang, China.
Mingyan ShiCollege of Life Science, Luoyang Normal University, Luoyang, Henan, China.
Xunping JiangCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
Long LiInstitute of Animal Science, Xizang Academy of Agricultural and Animal Husbandry Science, Lhasa, Xizang, China.
Guiqiong LiuCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
Wangsheng ZhaoSchool of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan, China.ORCID 0000-0002-6339-329X
Tianzeng SongInstitute of Animal Science, Xizang Academy of Agricultural and Animal Husbandry Science, Lhasa, Xizang, China.ORCID 0009-0005-3618-2293

Funding

Southwest University of Science and Technology (SWUST) Germplasm Innovation Project of Prolificacy Sheep in Xinjiang Agricultural Region (2023A02004)Southwest University of Science and Technology (SWUST) the Fundamental Research Funds for the Central Universities (2662020DKPY017)Southwest University of Science and Technology (SWUST) the National Natural Science Foundation of China (32160780)
6 · The paper itself

Abstract

Rumen flatulence is a diet-related rumen disease in ruminants. This study induced a rumen flatulence model in Xizang sheep using alfalfa (HRF) and wheatgrass (MRF). The aim was to understand the rumen microbiota diversity in healthy and pathological states, host-microbiota interactions, and the molecular mechanisms of rumen flatulence. Results showed that the pH in the HRF and MRF groups was lower than that in the natural grass group (LRF). SCFA concentrations varied between groups: in HRF, 2-BA and CA increased; in MRF, 4-MVA and 5-MCA rose. Microbial analysis indicated that the alpha- and beta-diversity of HRF and MRF groups were lower than LRF's, with different microbial compositions. Transcriptome analysis revealed many differentially expressed genes (DEGs). Compared to MRF, HRF had 348 upregulated and 511 downregulated DEGs. Versus LRF, MRF had 201 upregulated and 185 downregulated DEGs, while HRF had 128 upregulated and 238 downregulated DEGs. Spearman's correlation analysis showed that there was a positive correlation between

Indexed as

Medicago sativaRumenSheep DiseasesTriticumAnimal FeedAnimalsBacteriaGastrointestinal MicrobiomeGene Expression ProfilingMultiomicsSheepalfalfarumen flatulencerumen microorganismswheatXizang sheep

Identifiers

PMID40052788
PMCPMC11960438

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.