Evidence map›Paper›PMID 40052651›Full record

ArticleInternational journal of cancer2025

Delineation of monocytic and early-stage myeloid-derived suppressor cells in the peripheral blood of patients with hepatocarcinoma.

Marta Chivite-Lacaba, Iago Justo, Alberto Utrero-Rico, Oscar Caso, Cecilia González-Cuadrado, Manuel J Del Rey, Rocio Laguna-Goya, Javier Arroyo-Ródenas, Ángel Alfocea-Molina, Carlota C Ruigómez-Martín and 4 more

Abstract read
In one paragraph

Article in International journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Emerging Therapeutic Landscapes for KRAS-Mutant Pancreatic Ductal Adenocarcinoma: Beyond the "Undruggable" Paradigm.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marta Chivite-LacabaInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID 0000-0001-9357-5556
Iago JustoInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Alberto Utrero-RicoInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID 0000-0001-8814-8410
Oscar CasoInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Cecilia González-CuadradoInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID 0000-0001-9854-0870
Manuel J Del ReyInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Rocio Laguna-GoyaInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID 0000-0003-4265-8567
Javier Arroyo-RódenasInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Ángel Alfocea-MolinaInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Carlota C Ruigómez-MartínInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Manuel SerranoInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Lorena Pascual-PalaciosInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
María Esther ManceboInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID 0000-0002-1535-9062
Estela Paz-ArtalInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID 0000-0002-0646-2375

Funding

Fundación Científica Asociación Española Contra el Cáncer 2017/0068Instituto de Salud Carlos III CM22/00093Instituto de Salud Carlos III FI23/00275Instituto de Salud Carlos III PI22/00586Ministerio de Ciencia e Innovación FPU19/06393Private Proyect 2023/0089
6 · The paper itself

Abstract

In patients with hepatocellular carcinoma (HCC), increased myeloid-derived suppressor cells (MDSC) relate to aggressiveness and poor prognosis. Favorable responses with immune checkpoint inhibitors demonstrate that HCC is susceptible to immune activation, suggesting that the elimination of MDSC would provide therapeutic benefits. However, a global analysis of the different MDSC subsets in HCC is still missing. Here we phenotyped circulating myeloid cell subsets (monocytes, M-MDSC, PMN-MDSC and eMDSC) by flow cytometry in HCC and hepatocholangiocarcinoma patients and in healthy donors (HD). Isolated myeloid CD33

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMonocytesMyeloid-Derived Suppressor CellsAdultAgedArginaseCell ProliferationCytokinesFemaleHumansInterleukin-2 Receptor alpha SubunitMaleMiddle AgedSialic Acid Binding Ig-like Lectin 3ARG1 protein, humanArginaseCytokinesInterleukin-2 Receptor alpha SubunitSialic Acid Binding Ig-like Lectin 3hepatocarcinomaimmunosuppressionMDSCmyeloid derived suppressor cells

Identifiers

PMID40052651
PMCPMC12008823

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.