ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Visual-somatosensory integration as a novel behavioral marker of amyloid pathology.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Effectiveness of Multisensory Stimulation on Cognitive Function in Older Adults With Mild Cognitive Impairment: Protocol for a Systematic Review.JMIR research protocols · 2026Article
- Plaque-associated Microglial Polarization in Visual Brain Regions of the 5xFAD Mouse Model.bioRxiv : the preprint server for biology · 2026Article
- Cognitive Impairment Is Associated with Disrupted Motor Planning in Older Adults.Neuro-degenerative diseases · 2026Article
- Plaque-associated microglial polarization in visual brain regions of the 5xFAD mouse model.Frontiers in aging neuroscience · 2026Article
- Pathological and Structural Alterations of the Visual Pathway in APP/PS1 Mice: A Spatiotemporal Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Measuring Multisensory Integration in Clinical Settings: Comparing an Established Laboratory Method with a Novel Digital Health App.Brain sciences · 2025Article
- Visual-somatosensory integration as a novel behavioral marker of amyloid pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
introductionThe ability to integrate information across sensory modalities is a vital aspect of everyday functioning and is linked to cognition. Increasing evidence suggests that Alzheimer's disease (AD) pathology manifests in sensory association areas before appearing in higher-order cognitive areas. We examined the role of visual-somatosensory integration (VSI) as a novel behavioral marker of AD-associated amyloid pathology.
methodsThis cross-sectional study included 243 adults (77 ± 6.5 years; 52% female) who completed the VSI test and AD biomarker assays. The magnitude of VSI was the independent variable and amyloid-beta probability scores (APS; PrecivityAD
resultsLinear regression revealed an inverse association between the magnitude of VSI and APS (β = -0.16; p ≤ 0.01). As cognitive impairment increased from normal to dementia, the magnitude of VSI decreased (p < 0.05). DISCUSSION: Findings provide support for VSI impairment as a new behavioral marker of AD-associated amyloid pathology. HIGHLIGHTS: Here we provide support for the magnitude of VSI as a novel behavioral marker of AD-associated amyloid pathology given its significant association with an established, accurate, and reliable biomarker of AD pathology. Adults with normal cognition maintained the highest magnitude of VSI and brain amyloid negative scores. As cognitive impairment increased, the mean magnitude of VSI significantly decreased while amyloid probability scores (APS) increased. In fact, individuals with dementia revealed the lowest magnitude of VSI and the highest APS. Our research continues to emphasize the importance of successful multisensory integration in aging, where the establishment of future novel multisensory-based interventions aimed at preventing disability and optimizing independence could prove valuable.
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