Trial reportThe clinical respiratory journal2025
Bacterial Colonization of Silver-Additive Ventilator Circuit in Patients Receiving Mechanical Ventilation: A Randomized Controlled Trial.
Trial report in The clinical respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04927806 (The Effectiveness of Antimicrobial Breathing System on the Presence of Multidrug-resistant Organisms), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effectiveness of Antimicrobial Breathing System on the Presence of Multidrug-resistant Organisms
Who cites it
2 citing papers in PubMed.
- Invasive ventilator exhaust in critical care: aerosol transmission risks and management strategies-a narrative review.Critical care (London, England) · 2025Review
- Veterinary Clinics as Reservoirs forAntibiotics (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionMechanical ventilation is a significant risk factor for developing ventilator-associated pneumonia. Although silver-coated endotracheal tubes have been shown to reduce the bacterial burden, the efficacy of silver-based ion additive ventilator circuits in reducing bacterial colonization remains unclear.
methodsThis single-site, randomized controlled trial compared the incidence of bacterial contamination between a silver-additive ventilator circuit and a ventilator circuit that did not have a silver additive. Bacterial samples were collected from the inspiratory limb and Y-adaptor of the circuit and analyzed using culture and identification methods.
resultsBacterial growth was observed in all samples from the control group and in 93.7% and 81.2% of inspiratory limb and Y-adaptor samples, respectively, from the study group. The colony counts in the inspiratory limb samples were significantly different between the groups, with a higher proportion of undesirable colony counts in the control group compared with the study group. No significant difference between the groups was observed in the colony counts in the Y-adaptor samples.
conclusionThe use of a silver-additive ventilator circuit may reduce bacterial circuit colonization. However, further research with larger sample sizes and more diverse patient populations is necessary to confirm these findings.
trial registrationClinicalTrial.gov: NCT04927806.
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Registered trials
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