Evidence map›Paper›PMID 40052515›Full record

ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2025

Effect of 0.025% atropine on ocular biometry changes during accommodation.

Rohan P J Hughes, Emily C Woodman-Pieterse, Scott A Read, Stephen J Vincent, Michael J Collins

Abstract read
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Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Effect of 0.025% atropine on ocular biometry changes during accommodation.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rohan P J HughesCentre for Vision and Eye Research, Contact Lens and Visual Optics Laboratory, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0003-1770-527X
Emily C Woodman-PieterseCentre for Vision and Eye Research, Contact Lens and Visual Optics Laboratory, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0001-6032-7310
Scott A ReadCentre for Vision and Eye Research, Contact Lens and Visual Optics Laboratory, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0002-1595-673X
Stephen J VincentCentre for Vision and Eye Research, Contact Lens and Visual Optics Laboratory, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0002-5998-1320
Michael J CollinsCentre for Vision and Eye Research, Contact Lens and Visual Optics Laboratory, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0001-5226-5498

Funding

Children's Hospital Foundation
6 · The paper itself

Abstract

purposeLow concentration atropine is an effective treatment to slow myopia progression and axial elongation and also reduces accommodation. On-axis ocular dimensions of the eye change during accommodation; hence, this study aimed to quantify the effect of 0.025% atropine eye drops on accommodation-induced changes in ocular biometry.

methodsTwenty-eight myopic participants with a mean (SD) age of 17.0 (6.0) years (range: 8.0-25.5 years) and spherical equivalent refraction (SER) of -2.03 (1.05) D (range: -0.75 to -4.38 D) were enrolled. Baseline ocular biometry measurements of the left eye were captured using an optical biometer (Zeiss IOLMaster 700) for 0, 2, 4 and 6 D accommodation stimuli, presented via a Badal optometer. The accommodation response (AR) was determined using wavefront aberrometry (Imagine Eyes irx3) for the same accommodation stimuli and following cycloplegia using 1% tropicamide. Participants instilled 0.025% atropine eye drops nightly for 1 week in both eyes, and ocular biometry measurements were repeated on the day after the final atropine dose.

resultsAnterior chamber depth (ACD) and corrected vitreous chamber depth (cVCD) decreased, and crystalline lens thickness (LT), anterior segment length (ASL), crystalline lens centre position (LCP) and the AR increased significantly during accommodation (all p ≤ 0.009). Accommodation-induced changes in ACD and LT were reduced following 0.025% atropine use (both p ≤ 0.01), with significant pre- and post-atropine differences for the 4 and 6 D stimuli (all pairwise comparisons, p ≤ 0.004). On average, ACD, ASL and LCP increased, while cVCD, corrected axial length (cAL), and the AR decreased following 1 week of 0.025% atropine use (all p ≤ 0.002).

conclusionsThe AR and on-axis ocular biometric changes during accommodation were reduced following 1 week of 0.025% atropine use. These findings may have implications for the association between near work and myopia, and atropine's mechanism of action in humans.

Indexed as

Accommodation, OcularAtropineBiometryMyopiaRefraction, OcularAdolescentAdultAxial Length, EyeChildFemaleHumansMaleMydriaticsOphthalmic SolutionsYoung AdultAtropineMydriaticsOphthalmic Solutionsaccommodationatropinemyopiamyopia controlnear workocular biometry

Identifiers

PMID40052515
PMCPMC11976513

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.