Observational studyJournal of diabetes investigation2025
Clinical features among adult-onset type 1 diabetes, distribution of subtypes, and differences in probable and definite slowly progressive insulin-dependent diabetes mellitus: A single hospital-based study over a 13-year period.
Observational study in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Clinical characteristics and disease progression of typical adult-onset type 1 diabetes and insulin-dependent latent autoimmune diabetes in adults.Journal of diabetes investigation · 2026Article
- Differences in clinical characteristics between definite and probable slowly progressive insulin-dependent diabetes mellitus in real-world clinical settings in Japan (JDDM 79).Diabetology international · 2025Article
- Fulminant and Slowly Progressive Type 1 Diabetes Associated with Pregnancy.International journal of molecular sciences · 2025Review
- Update on slowly progressive type 1 diabetes.Journal of diabetes investigation · 2025Article
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Authors and funding
5 authors.
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Abstract
aimsIn Japan, type 1 diabetes (T1D) is classified into three subtypes based on its onset patterns; however, the proportion of each subtype remains unexplored. To elucidate the heterogeneity in adult-onset type 1 diabetes, we compared the frequencies of subtypes and clinical features by age at onset. MATERIALS AND
methodsThis cross-sectional, observational, single-institution study included 482 individuals (161 male) with T1D. The clinical and laboratory data, including glutamic acid decarboxylase autoantibodies, were extracted from the medical records.
resultsThe number of adults who developed T1D decreased with age. Among all patients, 62% (n = 299) had acute-onset T1D, 27% (n = 131) had slowly progressive T1D (SPIDDM), and 11% (n = 52) had fulminant T1D. The proportion of patients with fulminant T1D was approximately equivalent in all age groups; however, the percentage of patients with acute-onset T1D decreased from 78% in the 20-29 age group to 27% in the 70-79 age group. The proportion of patients with SPIDDM significantly increased with age, ranging from 16% in the 20-29 age group to 60% in the 70-79 age group. Among patients with SPIDDM, the prevalence of definite SPIDDM was 89%, and this prevalence did not differ based on the age at onset. Body mass index and C-peptide levels among patients with probable SPIDDM were significantly higher than those among patients with definite SPIDDM.
conclusionsThe proportion of adult-onset T1D subtypes differed according to the age at onset. In adult-onset T1D, some etiological differences may be based on age at onset.
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