Evidence map›Paper›PMID 40052414›Full record

ArticleACS chemical biology2025

Structural and Mechanistic Characterization of the Flavin-Dependent Monooxygenase and Oxidase Involved in Sorbicillinoid Biosynthesis.

Gwen Tjallinks, Nicolò Angeleri, Quoc-Thai Nguyen, Barbara Mannucci, Mark Arentshorst, Jaap Visser, Arthur F J Ram, Marco W Fraaije, Andrea Mattevi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gwen TjallinksDepartment of Biology and Biotechnology, University of Pavia, Via Adolfo Ferrata 9, Pavia 27100, Italy.
Nicolò AngeleriDepartment of Biology and Biotechnology, University of Pavia, Via Adolfo Ferrata 9, Pavia 27100, Italy.
Quoc-Thai NguyenFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang Street, Ben Nghe Ward, District 1, Ho Chi Minh City 70000, Vietnam.
Barbara MannucciDepartment of Biology and Biotechnology, University of Pavia, Via Adolfo Ferrata 9, Pavia 27100, Italy.
Mark ArentshorstFungal Genetics and Biotechnology, Institute of Biology Leiden, Leiden University, Sylviusweg 72, Leiden 2333 BE, The Netherlands.
Jaap VisserFungal Genetics and Biotechnology, Institute of Biology Leiden, Leiden University, Sylviusweg 72, Leiden 2333 BE, The Netherlands.
Arthur F J RamFungal Genetics and Biotechnology, Institute of Biology Leiden, Leiden University, Sylviusweg 72, Leiden 2333 BE, The Netherlands.
Marco W FraaijeBiomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 3, Groningen 9747 AG, The Netherlands.ORCID 0000-0001-6346-5014
Andrea MatteviDepartment of Biology and Biotechnology, University of Pavia, Via Adolfo Ferrata 9, Pavia 27100, Italy.ORCID 0000-0002-9523-7128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sorbicillinoids are yellow secondary metabolites synthesized through an elegant combination of enzymatic and spontaneous biochemical processes. The flavin-dependent monooxygenase SorC and oxidase SorD are crucial in this interplay, enabling the generation of a diverse array of functionally complex sorbicillinoids. By solving the crystal structures of SorC and SorD from

Indexed as

Mixed Function OxygenasesPenicillium chrysogenumAspergillus nigerCatalytic DomainCRISPR-Cas SystemsCrystallography, X-RayDinitrocresolsFlavin-Adenine DinucleotideFlavinsFungal ProteinsModels, MolecularOxidoreductasesProtein ConformationResorcinols4,6-dinitro-o-cresolDinitrocresolsFlavin-Adenine DinucleotideFlavinsFungal ProteinsMixed Function OxygenasesOxidoreductasesResorcinols

Identifiers

PMID40052414
PMCPMC11934079

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.