Evidence map›Paper›PMID 40052391›Full record

ArticleEuropean journal of neurology2025

Microglial Activation Visualized by [

Jingguo Wang, Jingjie Ge, Bo Deng, Huamei Lin, Wenbo Yang, Tianyang Sheng, Weijun Tang, Hai Yu, Xiang Zhang, Yarong Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
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  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jingguo WangDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-9527-3359
Jingjie GeDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Bo DengDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Huamei LinDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Wenbo YangDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Tianyang ShengDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Weijun TangDepartment of Radiology, Huashan Hospital, Shanghai, China.
Hai YuDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiang ZhangDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Yarong LiDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoni LiuDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-1101-4013
Chuantao ZuoDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Xiangjun ChenDepartment of Neurology and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-8108-9013

Funding

Science and Technology Commission of Shanghai Municipality 2017SHZDZX01
6 · The paper itself

Abstract

background and purposeWhether microglial activation plays an important role in the pathogenesis of autoimmune encephalitis (AE), such as anti-leucine-rich, glioma-inactivated-1 (LGI1) encephalitis, remains unknown. [

methodsPatients with anti-LGI1 encephalitis and non-inflammatory controls (NIC) underwent [

resultsForty-six patients with anti-LGI1 encephalitis were included in this study. Increased TSPO uptake was identified in the hippocampus, frontal cortex, and caudate nucleus. Montreal Cognitive Assessment (MoCA) score was significantly correlated with SUVRc in the hippocampus (R

conclusionMicroglial activation visualized by [

Indexed as

AutoantibodiesEncephalitisMicrogliaPositron-Emission TomographyPyrazolesPyrimidinesAcetamidesAdultAgedBiomarkersFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedPrognosisAcetamidesAutoantibodiesBiomarkersIntracellular Signaling Peptides and ProteinsLGI1 protein, humanN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamideN,N-diethyl-2-(2-(4-methoxyphenyl)-5,7-dimethyl-pyrazolo(1,5-a)pyrimidin-3-yl)-acetamidePyrazolesPyrimidinesReceptors, GABATSPO protein, humananti‐leucine‐rich glioma‐inactivated 1protein encephalitisbiomarkermicrogliaprognosistranslocator protein

Identifiers

PMID40052391
PMCPMC11886409

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.