Article in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07224178 (Left Atrial Strain), which is not on this map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Gabriele MasiniPisa University Hospital, Cardiology Division, University of Pisa, Italy (G.M., R.D.C.).ORCID 0000-0003-4220-3271
Wendy WangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (W.W.).ORCID 0000-0001-6025-0173
Anne EatonDivision of Biostatistics and Health Data Science, School of Public Health University of Minnesota, Minneapolis (A.E.).ORCID 0000-0001-5900-9745
Riccardo M InciardiBrescia University Hospital, Cardiology Division, University of Brescia, Italy (R.M.I.).ORCID 0000-0003-4846-8529
Elsayed Z SolimanDepartment of Internal Medicine, Cardiovascular Medicine Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.).ORCID 0000-0001-5632-8150
Rod S PassmanDivision of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, IL (R.S.P.).ORCID 0000-0001-8718-1534
Scott D SolomonDepartment of Cardiology, Harvard Medical School, Boston, MA (S.D.S.).ORCID 0000-0003-3698-9597
Amil M ShahDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.M.S.).ORCID 0000-0003-1056-4451
Raffaele De CaterinaPisa University Hospital, Cardiology Division, University of Pisa, Italy (G.M., R.D.C.).ORCID 0000-0003-1637-574X
Lin Yee ChenLillehei Heart Institute and Department of Medicine, University of Minnesota Medical School, Minneapolis (L.Y.C.).ORCID 0000-0002-0700-814X
Funding
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
Mapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5M
Cardiovascular Disease Epidemiology &Prevention TrngT32HL007779 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PAMELA L. Lutsey, JAMES S PANKOW · 1994 to 2026
$9.3M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2022 to 2025
$5.0M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF · 2022 to 2025
$4.7M
Cognitive Impairment and Dementia, Vascular Brain Injury, and Atrial Myopathy: Implications for Prevention of Alzheimer's Disease-Related DementiasRF1NS135615 · NINDS · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE, MOSLEY, THOMAS H · 2023 to 2023
$4.4M
Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related DementiasRF1NS127266 · NINDS · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE, GONZALEZ, HECTOR M · 2022 to 2022
$4.1M
Early Detection of Transthyretin Cardiac Amyloidosis: Defining a Novel Target for HFpEF Treatment and Prevention in Late LifeR01HL150342 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DORBALA, SHARMILA, SHAH, AMIL M · 2020 to 2023
$4.1M
Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related DementiasR01AG075883 · NIA · JOHNS HOPKINS UNIVERSITY · PI Lin Yee Chen, Ciprian M Crainiceanu · 2022 to 2026
$3.8M
Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling ElderlyR01HL126637 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2016 to 2020
backgroundVarious measures of abnormal left atrial (LA) structure or function (LA myopathy) are associated with a higher risk of ischemic stroke and dementia, independent of atrial fibrillation. However, limited data exist on their prognostic usefulness. Therefore, we aimed to assess the ability of markers of LA myopathy to improve the prediction of ischemic stroke and dementia.
methodsThe ARIC study (Atherosclerosis Risk in Communities) is a prospective community-based cohort study. For this analysis, we included participants who attended visit 5 (2011-2013) without a history of stroke or atrial fibrillation and had a 12-lead ECG and a transthoracic echocardiogram. Markers of LA myopathy included P wave abnormalities from 12-lead ECG, NT-proBNP (N-terminal pro-B-type natriuretic peptide), and LA volume and strain parameters from the echocardiogram. The primary composite outcome comprised ischemic stroke and dementia, which were ascertained through hospital surveillance, cohort follow-up, and death registries. To determine improvement in risk prediction of the composite outcome, each marker was individually added to a model that included CHA
resultsAmong 4712 participants (59% female; mean age, 74 years), 193 ischemic strokes and 769 dementia cases were ascertained over a median follow-up of 8.3 years. Of LA myopathy markers, only LA reservoir strain and NT-proBNP significantly improved C statistic when added to the CHA
conclusionsOf various LA myopathy markers, LA reservoir yields the greatest improvement in the prediction of ischemic stroke and dementia, supporting its use to identify people at high risk of cerebrovascular events and dementia.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Markers of Left Atrial Myopathy: Prognostic Usefulness for Ischemic Stroke and Dementia in People in Sinus Rhythm. · full record | OpenQuestion