Evidence map›Paper›PMID 40052212›Full record

ReviewPolish journal of microbiology2025

Harnessing Monoterpenes and Monoterpenoids as Weapons against Antimicrobial Resistance.

Amanda Shen-Yee Kong, Swee-Hua Erin Lim, Wan-Hee Cheng, Mohd Hafis Yuswan, Ngai-Paing Tan, Kok-Song Lai

Abstract readReview
In one paragraph

Review in Polish journal of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Whole-Genome Sequence Dataset ofMolecules (Basel, Switzerland) · 2026
    Article
  2. Veterinary sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amanda Shen-Yee KongSchool of Pharmacy, Monash University Malaysia, Subang Jaya, Malaysia.
Swee-Hua Erin LimHealth Sciences Division, Abu Dhabi Women's College, Higher Colleges of Technology, Abu Dhabi, United Arab Emirates.
Wan-Hee ChengFaculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia.
Mohd Hafis YuswanHalal Products Research Institute, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Ngai-Paing TanDepartment of Land Management, Faculty of Agriculture, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.
Kok-Song LaiHealth Sciences Division, Abu Dhabi Women's College, Higher Colleges of Technology, Abu Dhabi, United Arab Emirates.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses a formidable challenge in global healthcare, driving the exploration of natural products for novel antimicrobials. Among these, essential oils (EOs) derived from medicinal plants are rich sources of diverse bioactive compounds. Monoterpenes and monoterpenoids, critical constituents of EOs, have emerged as promising agents in combating multidrugresistant (MDR) pathogens. This review analyzed recent literature on the efficacy of monoterpenes against AMR, highlighting their broad-spectrum activity and potential as alternative therapeutic options for MDR infections. Mechanistic insights reveal their ability to disrupt cell membranes, inhibit biofilm formation, and modulate gene expression linked to virulence and resistance, thereby reducing microbial viability through alterations in membrane potential, enzymatic activity, and genetic regulation. Synergistic interactions between monoterpenes and conventional antibiotics are also elucidated. Innovative approaches in monoterpene research are explored, although challenges such as resistance, limited solubility, volatility, and potential toxicity are acknowledged, emphasizing the need for advanced formulation strategies and interdisciplinary research. The synergy observed with conventional antibiotics, coupled with their ability to target specific microbial resistance mechanisms, underscores the potential of monoterpenes in combating antibioticresistant infections. Future investigations should prioritize optimizing monoterpenes' therapeutic properties and assessing their safety profiles to fully exploit their potential in addressing AMR.

Indexed as

Anti-Bacterial AgentsBacteriaDrug Resistance, Multiple, BacterialMonoterpenesBiofilmsDrug SynergismHumansOils, VolatileAnti-Bacterial AgentsMonoterpenesOils, Volatileantimicrobial resistanceessential oilsmonoterpenesmultidrug resistance

Identifiers

PMID40052212
PMCPMC11949389

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.