ArticleOrthopaedic journal of sports medicine2025
Preoperative Platelet-Rich Plasma Injections Decrease Inflammatory and Chondrodegenerative Biomarkers in Patients With Acute Anterior Cruciate Ligament Tears: A Pilot Randomized Controlled Trial.
Article in Orthopaedic journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04088227 (Effect of Platelet Rich Plasma Injections on Inflammatory and Chondrodegenerative Biomarkers in Patients With Acute Anterior Cruciate Ligament Tears), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Platelet Rich Plasma Injections on Inflammatory and Chondrodegenerative Biomarkers in Patients With Acute Anterior Cruciate Ligament Tears
Who cites it
1 citing paper in PubMed.
- Biologic Augmentation in Anterior Cruciate Ligament Reconstruction and Beyond: A Review of PRP and BMAC.Journal of clinical medicine · 2025Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Posttraumatic osteoarthritis occurs at an alarming rate after anterior cruciate ligament (ACL) injury and reconstruction (ACLR). Purpose/Hypothesis: The purpose of this pilot randomized controlled trial was to evaluate the preoperative effect of a 2-injection series of platelet-rich plasma (PRP) on the progression of inflammatory and chondrodegenerative biomarkers before ACLR. It was hypothesized that preoperative PRP injections would decrease the chondrotoxicity of the presurgical knee fluid. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 24 participants were randomized to either a control or an intervention group. Both groups received joint aspirations within the first 10 days after ACL injury (visit 1). In addition to joint aspiration at visit 1, the PRP group received a leukocyte-poor, nonactivated PRP injection at visit 1 and an additional PRP injection 5 to 12 days after the initial visit (visit 2). Joint fluid samples were harvested in both groups at the time of ACLR (visit 3). The joint fluid and PRP samples were subject to inflammatory and chondrodegenerative biomarker analysis for the following: interleukin (IL)-1ß, IL-10, IL-6, granulocyte-macrophage colony-stimulating factor, IL-5, interferon (IFN)-γ, tumor necrosis factor-α, IL-2, IL-4, and IL-8. Results: The final analysis was completed on 8 participants in the control group and 8 in the intervention group. At visit 1, no significant differences were observed in cytokine concentrations between the control and intervention groups. Between visits 1 and 3, the control group demonstrated significant decreases in IL-8 ( Conclusion: Intervention with aspiration combined with a 2-injection series of leukocyte-poor PRP in the acute ACL-injured knee resulted in a significant reduction in effusion inflammatory markers, whereas the control aspiration (without PRP injections) did not show such marker reduction. Registration: NCT04088227 (ClinicalTrials.gov identifier).
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