Evidence map›Paper›PMID 40052149›Full record

ArticleFrontiers in cell and developmental biology2025

Evidence for Fgf and Wnt regulation of

Jessica C Britton, Anett Somogyi-Leatigaga, Billy A Watson, Endika Haro, Cassidy G Mulder, Kari D Kennedy, Allen M Cooper, Kristen L Whitley, Ruth-Love Yeboah, Jeanyoung Kim and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jessica C BrittonDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Anett Somogyi-LeatigagaDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Billy A WatsonDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Endika HaroDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Cassidy G MulderDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Kari D KennedyDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Allen M CooperDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Kristen L WhitleyDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Ruth-Love YeboahDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Jeanyoung KimDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Micah C YuDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Jairo D CamposDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Japhet AmoahDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Shimako KawauchiUC Irvine Transgenic Mouse Facility, University of Irvine, Irvine, CA, United States.
Eunyoung KimUC Irvine Transgenic Mouse Facility, University of Irvine, Irvine, CA, United States.
Charmaine U PiraDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.
Kerby C ObergDepartment of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, United States.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

Introduction: In vertebrate limb morphogenesis, wingless-related integration site (Wnt) proteins and fibroblast growth factors (Fgfs) secreted from the apical ectodermal ridge (AER) coordinate proximodistal outgrowth. Fgfs also sustain sonic hedgehog (Shh) in the zone of polarizing activity (ZPA). Shh directs anteroposterior patterning and expansion and regulates AER- Methods/Results: We have identified two limb-specific Discussion: These results suggest a role for Ets and Tcf/Lef transcription factors in the regulation of

Indexed as

cis-regulatory moduleETSFGFsgene regulationLhx2Tcf/Lefvertebrate limb developmentWnt

Identifiers

PMID40052149
PMCPMC11882541

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.