ArticleFrontiers in surgery2025
Fluorescence intensity of parathyroid glands in thyroid and parathyroid surgery: a near-infrared autofluorescence study.
Article in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Indocyanine green (ICG) guided thyroidectomy versus conventional thyroidectomy and the impact on parathyroid function preservation: an updated GRADE-assessed systematic review and meta-analysis.Langenbeck's archives of surgery · 2026Pooled it
- Intraoperative near-infrared autofluorescence in parathyroidectomy: associations with gland morphology, body mass index, and histopathology.Gland surgery · 2026Article
- A novel automated parathyroid glands detection and segmentation method in thyroidectomy.BMC surgery · 2026Article
- Enhanced parathyroid identification and preservation in total thyroidectomy using combined near-infrared autofluorescence and carbon nanoparticles.Frontiers in surgery · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
Objective: Near-infrared autofluorescence (NIRAF) imaging shows promise in identifying parathyroid gland (PG) during surgery. However, the clinical application of NIRAF faces challenges due to the heterogeneous fluorescence intensity (FI) of PGs observed in different thyroid and parathyroid diseases. This study aimed to evaluate the effectiveness of NIRAF in PG detection and to analyze the FI of PGs in patients with various thyroid and parathyroid diseases. Methods: A total of 105 patients undergoing thyroidectomy and parathyroidectomy were enrolled. Intraoperative NIRAF imaging was used to detect PGs, and the FI values were quantified using ImageJ software. Normal PGs were grouped according to the pathological results of ipsilateral thyroid diseases. Compare and analyze the FI values of normal and diseased PGs. Results: A total of 239 PGs were detected during surgery. 225 PGs were identified by NIRAF. The NIRAF identification rate was significantly higher than visual identification (94.1% vs. 81.2%, Conclusions: NIRAF demonstrates high efficiency in identifying PGs across various surgical stages, outperforming conventional visual identification. The FI of superior and inferior PGs exhibits significant variability across different intraoperative stages. Surgeons should exercise caution when identifying PGs in patients with primary hyperparathyroidism and hyperthyroidism, as these conditions are associated with lower FI compared to other thyroid diseases.
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