Evidence map›Paper›PMID 40051977›Full record

ArticleFrontiers in neurology2025

Apolipoprotein E genotype is associated with island sign in lobar intracerebral hemorrhage.

Qiong Yang, Haixin Sun, Xinran Ma, Lu Tang, Xiaolu Liu, Xin Huang, Xiao Huang, Yong Chen, Danyang Tian, Xiangzhu Zeng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qiong Yang *Department of Neurology, Peking University Third Hospital, Beijing, China.
Haixin Sun *Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xinran MaDepartment of Neurology, Peking University Third Hospital, Beijing, China.
Lu TangDepartment of Neurology, Peking University Third Hospital, Beijing, China.
Xiaolu LiuDepartment of Neurology, Peking University Third Hospital, Beijing, China.
Xin HuangDepartment of Neurology, Peking University Third Hospital, Beijing, China.
Xiao HuangDepartment of Neurology, Peking University Third Hospital, Beijing, China.
Yong ChenDepartment of Neurology, Peking University Third Hospital, Beijing, China.
Danyang TianDepartment of Neurology, Peking University Third Hospital, Beijing, China.
Xiangzhu ZengDepartment of Radiology, Peking University Third Hospital, Beijing, China.
Nan LiSchool of Public Health Department of Epidemiology and Biostatistics, Peking University, Beijing, China.
Wenzhi WangBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dongsheng FanDepartment of Neurology, Peking University Third Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The island sign is a predictor of hematoma expansion and worse outcomes in patients of spontaneous primary intracerebral hemorrhage (ICH). The biological mechanism of the island sign remains unclear, but its presence might be influenced by the underlying vasculopathy related to Apolipoprotein E ( Methods: We enrolled patients with primary supratentorial ICH in a multicenter cohort in northern China with baseline noncontrast CT images performed within 14 days after symptoms onset and Results: Among 460 patients enrolled, 122 were lobar ICH. In all patients, after adjusting for age, sex, hypertension, and time to CT, the presence of the Conclusion: The

Indexed as

APOE genotypecerebral amyloid angiopathygeneticsintracerebral hemorrhageisland sign

Identifiers

PMID40051977
PMCPMC11882416

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