ArticlePlastic and reconstructive surgery. Global open2025
An Innovative Lip Boosting Technique Using Polynucleotides: "4-point Cannula Technique".
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Comparative Effects of Injectable Biostimulatory Agents (Calcium Hydroxyapatite, New Cellular Treatment Factor, VAMP, and Human Exosomes) and Their Combination on Skin Regeneration.Aesthetic surgery journal. Open forum · 2026Article
- Beneficial Effect of Polydeoxyribonucleotide in the Treatment of Actinic Cheilitis: A Case Report.Cureus · 2025Article
- Tear Trough Rejuvenation With Injectable Biostimulatory Polynucleotides (VAMP).Plastic and reconstructive surgery. Global open · 2025Article
- Dual-plane Product Technique for Earlobe Rejuvenation: Apriline Hyaluronic Acid Filler and Apriline Skin Booster Injection.Plastic and reconstructive surgery. Global open · 2025Article
- Combination of Hyaluronic Acid and Polynucleotides Injection for the Treatment of Cheilitis Simplex.Clinical, cosmetic and investigational dermatology · 2025Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
The new concept in aesthetic medicine is heading toward regenerative medicine and the use of skin boosters in our practice, so the present case report aimed to evaluate the efficacy of injecting a polynucleotide into the lips for lip rejuvenation. Five female Middle Eastern patients were included in the study who wanted to have a lip rejuvenation treatment aiming to provide a lip hydration effect without any volumization. All patients were injected with polynucleotide using a micro cannula. Standardized photographs were taken before and after the injection procedure for evaluation of the results. All patients reported a high degree of satisfaction immediately after the injection, and there was also a marked improvement in the lip texture and elasticity where this improvement lasted 6 months after the procedure. Using polynucleotide as a skin booster for lip rejuvenation can provide a hydrating effect for the lips without any volumization, along with improvement in the lip texture, where this improvement lasts for 6 months after the procedure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.