ArticleHeliyon2025
Comparison of interstitial lung disease diagnoses in urban and rural areas among participants in the pulmonary fibrosis foundation patient registry.
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Rural and urban environmental exposures and the risk of progressive pulmonary fibrosis.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about differences in interstitial lung disease (ILD) diagnosis by geographic location. The aim of this study is to evaluate differences in cross-sectional ILD diagnosis between patients in urban and rural areas. Methods: This is a retrospective analysis of participants (n = 1992) in the Pulmonary Fibrosis Foundation (PFF) Patient Registry. Diagnoses were grouped as follows: idiopathic pulmonary fibrosis (IPF); idiopathic interstitial pneumonia other than IPF (IIP, non-IPF); connective tissue disease-associated ILD (CTD-ILD); fibrotic hypersensitivity pneumonitis (fibrotic HP); exposure-related ILD; and other ILDs. Patient-reported zip codes were mapped to county Federal Information Processing Series (FIPS) codes using data from U.S. Department of Housing and Urban Development (HUD). Frequencies of ILD diagnoses were compared between urban and rural groups using two-sample Z-test with 0.05 significance level. County-level variables including occupation and fuel use were then compared by ILD diagnosis using analysis of variance (ANOVA) with 0.05 significance level. Results: Median age at consent was 69 years, 63 % were male, and 89.5 % were white. By county classification, 12 % resided in a rural area. Rates of IPF, IIP (non-IPF), and CTD-ILD diagnosis were similar between urban and rural residents, however rates of fibrotic HP and exposure-related ILD were higher among rural residents. Residence in a county with coal fuel use or wood fuel use was higher among those with exposure-related ILD (p < 0.0001 and p = 0.0001, respectively). Conclusion: ILD diagnoses differ in urban versus rural ILD patients, with fibrotic HP and exposure-related ILD being significantly more prevalent among residents in rural areas. Type of fuel use also was associated with fibrotic HP and exposure-related ILD.
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