Evidence map›Paper›PMID 40051839›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Cofactor engineering for improved production of 2,4-dihydroxybutyric acid via the synthetic homoserine pathway.

Nadine Ihle, Laura Grüßner, Ceren Alkim, T A Stefanie Nguyen, Thomas Walther, Cláudio J R Frazão

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nadine IhleChair of Bioprocess Engineering, Institute of Natural Materials Technology, TU Dresden, Dresden, Germany.
Laura GrüßnerChair of Bioprocess Engineering, Institute of Natural Materials Technology, TU Dresden, Dresden, Germany.
Ceren AlkimToulouse Biotechnology Institute, UMR INSA-CNRS5504 and UMR INSA-INRAE 792, Toulouse, France.
T A Stefanie NguyenChair of Bioprocess Engineering, Institute of Natural Materials Technology, TU Dresden, Dresden, Germany.
Thomas WaltherChair of Bioprocess Engineering, Institute of Natural Materials Technology, TU Dresden, Dresden, Germany.
Cláudio J R FrazãoChair of Bioprocess Engineering, Institute of Natural Materials Technology, TU Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(L)-2,4-dihydroxybutyrate (DHB) is a versatile compound that can serve as a precursor for the synthesis of the methionine analog 2-hydroxy-4-(methylthio)butyrate and new advanced polymers. We previously implemented in

Indexed as

2,4-dihydroxybutyric acidcofactor specificityenzyme engineeringEscherichia colihomoserinestrain engineeringsynthetic metabolic pathway

Identifiers

PMID40051839
PMCPMC11882521

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.