Evidence map›Paper›PMID 40051779›Full record

ArticleResearch in autism spectrum disorders2023

Interactive associations of eczema with glutathione S-transferase genes in relation to autism spectrum disorder and its severity in Jamaican children.

Sepideh Saroukhani, Maureen Samms-Vaughan, Jan Bressler, MinJae Lee, Courtney Byrd-Williams, Manouchehr Hessabi, Megan L Grove, Sydonnie Shakespeare-Pellington, Katherine A Loveland, Mohammad H Rahbar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research in autism spectrum disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sepideh SaroukhaniDivision of Clinical and Translational Sciences, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA and Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Maureen Samms-VaughanDepartment of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Mona, Kingston 7, Jamaica.
Jan BresslerDepartment of Epidemiology, Human Genetics, and Environmental Sciences, and Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
MinJae LeeDepartment of Population & Data Sciences, and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Courtney Byrd-WilliamsDepartment of Health Promotion and Behavioral Sciences, and Michael & Susan Dell Center for Healthy Living, School of Public Health Regional Campus at Austin, The University of Texas Health Science Center at Houston, Austin, Texas 78701, USA.
Manouchehr HessabiBiostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Megan L GroveDepartment of Epidemiology, Human Genetics, and Environmental Sciences, and Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Sydonnie Shakespeare-PellingtonDepartment of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Mona, Kingston 7, Jamaica.
Katherine A LovelandLouis A. Faillace, MD Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Mohammad H RahbarDepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA and Division of Clinical and Translational Sciences, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA and Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

Funding

U OF TEXAS HLTH SCI CTR HOUSTON CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCESUL1RR024148 · NCRR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2006 to 2010
$27.9M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Epidemiological Research on Autism in Jamaica - Phase IIR01ES022165 · NIEHS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RAHBAR, MOHAMMAD HOSSEIN · 2013 to 2018
$2.8M
Epidemiological Research on Autism in JamaicaR21HD057808 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RAHBAR, MOHAMMAD HOSSEIN · 2009 to 2010
$278k
NCATS NIH HHS UL1 TR000371NCRR NIH HHS UL1 RR024148NICHD NIH HHS R21 HD057808NIEHS NIH HHS R01 ES022165
6 · The paper itself

Abstract

Background: Comorbidity of eczema with autism spectrum disorder (ASD) is increasing. We investigated the associations of eczema and its possible interaction with polymorphisms in glutathione S-transferase (GST) genes in relation to ASD and ASD severity. Method: Using data from 344 1:1 age- and sex-matched ASD cases and typically developing controls, we assessed additive and interactive associations of eczema with GST genes in relation to ASD by applying conditional logistic regression models, and in relation to ASD severity in ASD cases as measured by the Autism Diagnostic Observation Schedule-2nd Edition (ADOS-2) total and domain-specific comparison scores (CSs) by fitting general linear models. Results: After adjusting for child's age and history of breastfeeding, eczema had no additive association with ASD [Matched Odds ratio (MOR) and 95% Confidence Intervals (CI): 1.04 (0.76, 1.41), Conclusion: Our findings suggest children with certain genotypes for GST genes may be more susceptible for comorbidity of eczema and ASD, which is consistent with the role of GST genes in both conditions.

Indexed as

Autism Spectrum DisorderComorbidityEczemaGlutathione S-transferaseInteractionOxidative Stress

Identifiers

PMID40051779
PMCPMC11884259

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.