ArticleVeterinary record open2025
Immunological responses against bovine viral diarrhoea virus types 1 and 2 after administration of a commercial subunit vaccine measured by ELISA and serum neutralisation on serum and milk samples.
Article in Veterinary record open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Bovine Viral Diarrhea Virus and Vaccine Protection Strategies.Veterinary sciences · 2026Review
- Article
- Immunological responses against bovine viral diarrhoea virus types 1 and 2 after administration of a commercial subunit vaccine measured by ELISA and serum neutralisation on serum and milk samples.Veterinary record open · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Our study evaluated the antibody responses against bovine viral diarrhoea virus (BVDV)-1 and BVDV-2 generated by a novel subunit vaccine comprising BVDV-1 E2 and BVDV-2 E2 recombinant glycoproteins. Methods: Two trials were conducted. Cattle were given four intramuscular doses (D0, D21, D204 and D570) of 2 mL of vaccine (vaccinated) or phosphate-buffered saline (control). In the first trial, 20 young calves were randomly distributed into the vaccinated or control group. Blood samples were collected to assess BVDV antibodies by ELISA and neutralisation. In the second trial, heifers and cows from three farms were assigned to the vaccinated and control groups. Individual blood samples, bulk tank milk (BTM) and individual milk samples were obtained. The antibody response against BVDV was analysed using different ELISA kits. Neutralising antibodies against different BVDV isolates from Europe and North and South America were also assessed in this trial. Results: Compared with the control group, the vaccine induced significantly ( Conclusions: The vaccine induced a strong antibody response against BVDV-1 and BVDV-2; this response allowed infected and vaccinated animals to be differentiated (Differentiating Infected from Vaccinated Animals (DIVA) vaccine).
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Registered trials
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