Evidence map›Paper›PMID 40051690›Full record

ArticleJournal of functional foods2025

Profiling the response of individual gut microbes to free fatty acids (FFAs) found in human milk.

Megan E Waller, Alyssa Gutierrez, Taylor D Ticer, Janiece S Glover, John E Baatz, Carol L Wagner, Melinda A Engevik, Katherine E Chetta

Abstract read
In one paragraph

Article in Journal of functional foods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Omega-3 polyunsaturated fatty acids and gut microbiota.Current opinion in clinical nutrition and metabolic care · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Megan E WallerDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, United States.
Alyssa GutierrezDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, United States.
Taylor D TicerDepartment of Microbiology & Immunology, Medical University of South Carolina, United States.
Janiece S GloverDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, United States.
John E BaatzDepartment of Pediatrics, C.P. Darby Children's Research Institute, Medical University of South Carolina, United States.
Carol L WagnerDepartment of Pediatrics, C.P. Darby Children's Research Institute, Medical University of South Carolina, United States.
Melinda A EngevikDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, United States.
Katherine E ChettaDepartment of Pediatrics, C.P. Darby Children's Research Institute, Medical University of South Carolina, United States.

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
South Carolina Clinical & Translational Research Institute (SCTR)KL2TR001452 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCRAE-CLARK, AIMEE L · 2015 to 2024
$5.9M
Identifying the role of serotonin receptor 4 and trefoil factor 3 in intestinal wound repairK01DK123195 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ENGEVIK, MELINDA ANNE · 2020 to 2024
$612k
NCATS NIH HHS KL2 TR001452NCATS NIH HHS UL1 TR001450NIDDK NIH HHS K01 DK123195NIDDK NIH HHS P30 DK123704
6 · The paper itself

Abstract

Preterm infants have an immature intestinal environment featuring microbial dysbiosis. Human milk can improve the composition of the neonatal gut microbiome by supporting commensal species. Milk free fatty acids (FFAs) provide nutritional energy, participate in endogenous signaling, and exert antimicrobial effects. This study examined the growth of individual commensal and pathobiont microbes in response to unesterified unsaturated FFAs found in milk: oleic, linoleic, arachidonic, and docosahexaenoic acid. Select species of commensal and pathobiont genera (

Indexed as

BifidobacteriumDietEnterobacterEnterococcusFormulaFree fatty acidHuman breast milkIntestineKlebsiellaLactobacillusMicrobiomePathogensPremature infant

Identifiers

PMID40051690
PMCPMC11884519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.