ArticleFrontiers in chemistry2025
Construction of pH-responsive hydrogel coatings on titanium surfaces for antibacterial and osteogenic properties.
Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Hydrogel coatings for titanium implants: From smart stimuli-responsive strategies to multimodal bone regeneration.Bioactive materials · 2026Review
- Antimicrobial efficiency of pH-responsive PAA/PAH-coated and flucloxacillin loaded titanium implants in the Galleria mellonella model.Drug delivery and translational research · 2026Article
- Enhanced Cell Adhesion on Biofunctionalized Ti6Al4V Alloy: Immobilization of Proteins and Biomass fromInternational journal of molecular sciences · 2026Article
- Antimicrobial and Antiviral Activities, and Biocompatibility of Titanium Coated with Electron Beam-Irradiated α‑Silver Tungstate Microcrystals.ACS omega · 2025Article
- Recent progress of polydopamine nanoparticles as advanced antimicrobial nanomaterials.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection is one of the leading causes of failure in titanium-based implant materials during clinical surgeries, often resulting in delayed or non-union of bone healing. Furthermore, the overuse of antibiotics can lead to bacterial resistance. Therefore, developing a novel titanium-based implant material with both antimicrobial and osteogenic properties is of great significance. In this study, chitosan (CS), polydopamine (PDA), and antimicrobial peptides (AMPs) HHC36 were applied to modify the surface of titanium, resulting in the successful preparation of the composite material Ti-PDA-CS/PDA@HHC36 (abbreviated as T-P-C/P@H). CS promotes osteogenesis and cell adhesion, providing an ideal microenvironment for bone repair. PDA enhances the material's biocompatibility and corrosion resistance, offering cell adhesion sites, while both components exhibit pH-responsive characteristics. The HHC36 effectively prevents infection, protecting the bone repair material from bacterial damage. Overall, the synergistic effects of these components in T-P-C/P@H not only confer excellent antimicrobial and osteogenic properties but also improve biocompatibility, offering a new strategy for applying titanium-based implants in clinical settings.
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Registered trials
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