ArticleChemical science2025
Structure-property relationships for the force-triggered disrotatory ring-opening of cyclobutene.
Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Force-induced transition state rupture enables mechanistic control in aziridine mechanochemistry.Chemical science · 2025Article
- Structure-property relationships for the force-triggered disrotatory ring-opening of cyclobutene.Chemical science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Symmetry forbidden reactions are notoriously difficult to study experimentally, for the simple reason that their competing symmetry allowed pathways typically dominate. Covalent polymer mechanochemistry offers an opportunity to broaden access to symmetry forbidden reactions, through the judicious placement of polymer handles on mechanophore reactants. Here, single molecule force spectroscopy and computation are used to evaluate substituent effects on the disrotatory ring opening reaction of cyclobutene to butadiene. Theory and experiment reveal that the formally forbidden reaction is more sensitive to substituents on the scissile carbon-carbon bond than on the alkene, with each of two Me substituents providing approximately 1.5-2 kcal mol
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.