Evidence map›Paper›PMID 40051638›Full record

ArticleFrontiers in immunology2025

Hsa_circ_0001756 drives gastric cancer glycolysis by increasing the expression and stability of PGK1 mRNA.

Long Qian, Luman Wang, Hao Chen, Song Wang, Yinfen Hou, Li Xu, Yabin Xia, Maoqi Xu, Xiaoxu Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Long Qian *Department of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
Luman Wang *Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Hao Chen *Department of Oncology, Wuhu Conch Hospital, Wuhu, Anhui, China.
Song WangDepartment of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
Yinfen HouDepartment of Medical Examination Center, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
Li XuDepartment of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
Yabin XiaDepartment of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
Maoqi XuGeneral Surgery Department, Anhui Wannan Rehabilitation Hospital, The Fifth People's Hospital of Wuhu, Wuhu, Anhui, China.
Xiaoxu HuangDepartment of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Strategies for preventing high glycolysis in tumour cells are urgently needed. CircRNAs (circRNAs) play important roles in glycolysis. However, the mechanism underlying the effects of hsa_circ_0001756 in gastric cancer (GC) remains unclear. Methods: In this study, we detected the expression of hsa_circ_0001756 in GC tissues and cells using quantitative real-time polymerase chain reaction (qRT PCR). Construct a silencing and overexpression vector to validate the role of hsa_circ_0001756 in GC. Pulldown and RIP experiments were conducted to verify the identification of miRNA and protein binding to hsa_circ_0001756. Results: The expression level of hsa_circ_0001756 in GC tissues and cells is significantly upregulated. The expression level of hsa_circ_0001756 is closely related to TNM stage and tumour size in patients with GC. The proliferation and migration of hsa_circ_0001756-expressing cells Conclusion: This study provides a theoretical basis for designing drugs that target molecules related to energy metabolism in tumours and provides a new strategy for the clinical treatment of GC.

Indexed as

Gene Expression Regulation, NeoplasticGlycolysisPhosphoglycerate KinaseRNA, CircularRNA, MessengerStomach NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleHeterogeneous-Nuclear RibonucleoproteinsHumansMaleMicroRNAsMiddle AgedPolypyrimidine Tract-Binding ProteinHeterogeneous-Nuclear RibonucleoproteinsMicroRNAsPGK1 protein, humanPhosphoglycerate KinasePolypyrimidine Tract-Binding ProteinPTBP1 protein, humanRNA, CircularRNA, MessengercircRNAglycolysismiR-185-3pPGK1PTBP1

Identifiers

PMID40051638
PMCPMC11882586

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.