ArticleFrontiers in reproductive health2025
The correlation between sperm DNA methylation and DNA damage: a comparison of comet and TUNEL.
Article in Frontiers in reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the relationship between sperm DNA methylation and DNA damage as determined by the comet or TUNEL assays. Design: Retrospective research study. Setting: University-based andrology and Patients: Data came from 1,470 male partners (ages 18 and older) recruited from heterosexual couples (ages 18-45 years) seeking fertility treatments. These data were analyzed retrospectively from the Folic Acid and Zinc Supplementation Trial (FAZST) study. Main outcome measures: Comet and TUNEL measures and associations with DNA methylation patterns. Results: Comet and TUNEL values were correlated with one another across all samples ( Conclusions: Because the comet and TUNEL assays are both used to indicate levels of DNA damage, and outputs of both are correlated to each other, it would seem to follow that both are equally predictive of deviations in DNA methylation patterns. The findings of this study suggest that this is not the case. The comet assay shows a significantly higher association with DNA methylation disruption, and we therefore believe it to be a better indicator of sperm epigenetic health.
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