Evidence map›Paper›PMID 40051525›Full record

ArticleMaterials today. Bio2025

Biomimetic mineralized DCPA/ anti-CD47 containing thermo-sensitive injectable hydrogel for bone-metastatic prostate cancer treatment.

Shenglong Tan, Qianqian Wang, Chunxiang Feng, Xiaoyong Pu, Dong Li, Fenglian Jiang, Jian Wu, Shang Huang, Junhong Fan, Ruijuan Zhong and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shenglong TanDepartment of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Qianqian WangDepartment of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Chunxiang FengDepartment of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Xiaoyong PuDepartment of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Dong LiDepartment of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Fenglian JiangDepartment of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Jian WuDepartment of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Shang HuangDepartment of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Junhong FanDepartment of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Ruijuan ZhongDepartment of Operating Room, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Chunmiao MoDepartment of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Jiayu LuoDepartment of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Peiliang ZhongDepartment of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Jiumin LiuDepartment of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Dandan MaDepartment of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Strategies that leverage the phagocytic capabilities of M1 macrophages against tumor cells are currently being investigated for cancer treatment. However, the clinical application of these strategies is significantly hampered by the severe side effects associated with conventional M1 macrophage activators. In this study, biomimetic mineralized dicalcium phosphate anhydrous (MDCPA) was synthesized using Zein as an organic template, aiming to promote M1 macrophage polarization effectively while minimizing side effects.

Indexed as

Anti-tumor immunityBiomimetic mineralizationDCPAM1 macrophage polarizationProstate cancer bone metastasis

Identifiers

PMID40051525
PMCPMC11883399

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.