Evidence map›Paper›PMID 40051327›Full record

ArticleHuman brain mapping2025

Denoising Improves Cross-Scanner and Cross-Protocol Test-Retest Reproducibility of Diffusion Tensor and Kurtosis Imaging.

Benjamin Ades-Aron, Santiago Coelho, Gregory Lemberskiy, Jelle Veraart, Steven H Baete, Timothy M Shepherd, Dmitry S Novikov, Els Fieremans

Abstract read
In one paragraph

Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Normal appearing white matter and disability in multiple sclerosis.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benjamin Ades-AronBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.ORCID 0000-0001-5077-3341
Santiago CoelhoBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.ORCID 0000-0002-1039-4803
Gregory LemberskiyMicrostructure Imaging Inc., Brooklyn, New York, USA.
Jelle VeraartBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.
Steven H BaeteBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.
Timothy M ShepherdBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.
Dmitry S NovikovBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.
Els FieremansBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Li Feng · 2014 to 2026
$19.3M
Mesoscopic Biomarkers of Neurodegeneration with Diffusion MRIR01NS088040 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS, NOVIKOV, DMITRY S · 2014 to 2023
$5.2M
Random Matrix Theory-Based Noise Removal in MRIR01EB027075 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS, NOVIKOV, DMITRY S · 2019 to 2022
$2.7M
Fingerprinting-Based Neuronal Fiber Identification in Brain SurgeryR01EB028774 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAETE, STEVEN H. · 2020 to 2023
$1.9M
Multiscale Modeling of Brain Aging and Alzheimer’s Disease with MRI, Pathology and ProteomicsR21AG087904 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS · 2024 to 2025
$466k
Fast High-Resolution Microstructure Diffusion MRI Exploiting Data RedundancyK99EB036080 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COELHO, SANTIAGO · 2024 to 2025
$222k
NIA NIH HHS R21 AG087904NIBIB NIH HHS K99 EB036080NIBIB NIH HHS P41 EB017183NIBIB NIH HHS R01 EB027075NIBIB NIH HHS R01 EB028774NIH HHS K99 EB036080NIH HHS P41EB017183NIH HHS R01 EB027075NIH HHS R01 EB028774NIH HHS R01 NS088040NIH HHS R21AG087904NINDS NIH HHS R01 NS088040
6 · The paper itself

Abstract

The clinical translation of diffusion magnetic resonance imaging (dMRI)-derived quantitative contrasts hinges on robust reproducibility, minimizing both same-scanner and cross-scanner variability. As multi-site data sets, including multi-shell dMRI, expand in scope, enhancing reproducibility across variable MRI systems and MRI protocols becomes crucial. This study evaluates the reproducibility of diffusion kurtosis imaging (DKI) metrics (beyond conventional diffusion tensor imaging (DTI)), at the voxel and region-of-interest (ROI) levels on magnitude and complex-valued dMRI data, using denoising with and without harmonization. We compared same-scanner, cross-scanner, and cross-protocol variability for a multi-shell dMRI protocol (2-mm isotropic resolution, b = 0, 1000, 2000 s/mm

Indexed as

BrainDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingImage Processing, Computer-AssistedNeuroimagingWhite MatterAdultFemaleHumansMaleMiddle AgedReproducibility of ResultsYoung Adultbrain white matterclinical translationdiffusion kurtosis imagingdiffusion tensor imaginghigher‐order diffusionimage denoisingMPPCAtest–retest reproducibility

Identifiers

PMID40051327
PMCPMC11885890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.