Evidence map›Paper›PMID 40051266›Full record

ArticleAsian journal of andrology2025

A 10-year longitudinal analysis of the impact of demographic, lifestyle, and medical factors on semen qualities in men in a city in the midwestern region of the United States of America.

Malik Scott, Anaelena Rodriguez, Orry Marciano, Rachel Nordgren, Scott D Lundy, Omer A Raheem

Abstract read
In one paragraph

Article in Asian journal of andrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Malik ScottUniversity of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA.
Anaelena RodriguezUniversity of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA.
Orry MarcianoUniversity of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA.
Rachel NordgrenUniversity of Chicago Department of Public Health Sciences, Chicago, IL 60637, USA.
Scott D LundyCleveland Clinic Foundation, Cleveland Clinic, Cleveland, OH 44195, USA.
Omer A RaheemUniversity of Chicago Medical Center Department of Urology, Chicago, IL 60637, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractThis study was to survey the relationship between semen values and demographics, comorbidities, and recreational substance use in a large cohort of adult men at the University of Chicago Medical Center Department of Urology (Chicago, IL, USA). We performed an analysis from January 2013 to December 2023 of semen samples obtained from adult patients at our institution and collected their demographics, comorbid medical conditions, and recreational substance use information. Patients were divided into categories of normozoospermia, oligozoospermia, and azoospermia on the basis of the 5 th version of the World Health Organization (WHO) guidelines. Data were analyzed by univariate linear and logistic regression models, after which statistically significant variables were placed into multivariable models. Azoospermia and oligozoospermia were both associated with Caucasian or Black, Indigenous, and People of Color (BIPOC) race (both P < 0.001), increasing age ( P = 0.005 and P < 0.001, respectively), anemia ( P < 0.001 and P = 0.02, respectively), lifetime tobacco use (both P < 0.001), lifetime alcohol use ( P = 0.02 and P < 0.001, respectively), and lifetime use of at least two recreational substances ( P < 0.001 and P = 0.003, respectively) in multivariable models. Oligospermia was additionally associated with benign prostatic hyperplasia (BPH; P = 0.003) in multivariable models. This study suggests that at-risk populations may benefit from additional early screening and workup for infertility.

Indexed as

AzoospermiaLife StyleOligospermiaSemen AnalysisAdultComorbidityHumansLongitudinal StudiesMaleMiddle AgedMidwestern United StatesYoung Adultinfertilitymen’s healthmetabolic diseasesrace factorsrecreational drug use

Identifiers

PMID40051266
PMCPMC12279348

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.