ArticleAdvanced materials (Deerfield Beach, Fla.)2025
Cardiac Organoid Model Inspired Micro-Robot Smart Patch to Treat Myocardial Infarction.
Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Emerging bioactive microneedle platforms for disease management: From cutaneous disorders to systemic therapeutics.Bioactive materials · 2026Review
- Research advances in microneedle-exosome delivery systems for the treatment of multisystem diseases.Regenerative therapy · 2026Review
- Organoids: Current Applications and Future Directions.MedComm · 2026Review
- Inhaled formulations for bacterial pneumonia: Strategies and advances in drug delivery.Bioactive materials · 2026Review
- The synergistic applications of organoids and exosomes in disease modeling and disease treatment.Molecular biology reports · 2026Review
- Application of microneedle patches in the alleviation of cardiac infarction in animal models: a systematic review and meta-analysis.Journal of biological engineering · 2026Article
- From conceptual design to translational progress: Emerging advances in intelligent microneedles for biomedical applications.Acta pharmaceutica Sinica. B · 2026Review
- Endogenous and exogenous stimuli-driven intelligent nanocarriers: emerging strategies for the treatment of myocardial infarction.Journal of nanobiotechnology · 2026Review
- PRP-loaded pH-responsive hydrogel for the amelioration of ventricular remodeling following myocardial infarction.Materials today. Bio · 2026Article
- Microneedle-Enabled Exosome Therapy: From Tumor Targeting to Precision Treatment of Complex Diseases.International journal of nanomedicine · 2026Review
- Construction and applications of exosome-microneedle integrated systems.International journal of pharmaceutics: X · 2025Review
- Cardiac Development, Cellular Composition and Function: From Regulatory Mechanisms to Applications.Cells · 2025Review
- [Advances in hydrogel drug delivery systems for myocardial infarction treatment].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Review
- Cardiac Organoid Model Inspired Micro-Robot Smart Patch to Treat Myocardial Infarction.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Recent progress of nanomaterials for diagnosis and treatment of rejection in heart transplantation.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Post-myocardial infarction (MI), the rapid decrease in pH triggers myocardial cell acidosis, which compromises the therapeutic efficacy of exosomes in MI. The groundbreaking research in the human cardiac organoid MI model suggests that exosomes, when paired with pH adjustment, dramatically reduce cardiomyocyte mortality while maintaining their proliferative potential, underscoring the importance of pH regulation in myocardial preservation. Micro-robot mounted micro-needle (MN) patch is thus proposed, targeting MI-acidic microenvironmet, to deliver exosomes into deep injured tissue. Upon injection, the patch base releases VEGF-laden nanoparticles adhering to the infarcted myocardium. The smart patch is found not only 3D reconstructs the vascular network in MI regions but also effectively saves cardiomyocytes in rats. Furthermore, the minimally invasive delivery of MN patches are also verified to hearts of rabbits and pigs via thoracoscopic surgery underscores. These findings suggest that precise regulation of the microenvironment is a key to improving treatment outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.