Evidence map›Paper›PMID 40051230›Full record

ArticleAdvanced healthcare materials2025

In Situ-Gelling Antimicrobial Poly(oligoethylene glycol methacrylate)-Based Hydrogels Integrating Bound Quaternary Ammonia Compounds and Antibiotic Functionalities for Effective Infected Wound Healing.

Fei Xu, Evelyn Cudmore, Sadru-Dean Walji, Lei Zhang, Meghan Kostashuk, Isabella Jun, Gurpreet Randhawa, Zhicheng Pan, Todd Hoare

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fei XuDepartment of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.ORCID 0000-0003-2660-5211
Evelyn CudmoreDepartment of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.ORCID 0009-0008-5187-9277
Sadru-Dean WaljiDepartment of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.ORCID 0000-0003-4795-5050
Lei ZhangDepartment of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Meghan KostashukDepartment of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Isabella JunDepartment of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Gurpreet RandhawaDepartment of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Zhicheng PanDepartment of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Todd HoareDepartment of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.ORCID 0000-0002-5698-8463

Funding

Canada Research ChairsNatural Sciences and Engineering Research Council of Canada RGPIN-2017-64550
6 · The paper itself

Abstract

In situ-gelling antibacterial hydrogels are reported in which two antibacterial entities (quaternary ammonium (QA) groups and the antibiotic ciprofloxacin (CIP)) are tethered to a single precursor based on the anti-fouling polymer poly(oligoethylene glycol methacrylate) (POEGMA). Synergism between the QA and CIP tethers is demonstrated to enable broad-spectrum killing and/or disinfection of both gram-positive and gram-negative bacteria both in vitro and in vivo while also supporting improved functional recovery of uninjured skin morphology. Coupled with the suitable mechanics, swelling capacity, and stability of the gels, the multi-mechanism antibacterial properties of the hydrogels offer promise for treating or preventing infections of burn wounds.

Indexed as

Anti-Bacterial AgentsHydrogelsMethacrylatesPolyethylene GlycolsWound HealingAnimalsCiprofloxacinMiceMicrobial Sensitivity TestsQuaternary Ammonium CompoundsAnti-Bacterial AgentsCiprofloxacinHydrogelsMethacrylatesPolyethylene GlycolsQuaternary Ammonium Compoundsanti‐bacterial materialshydrogelsin situ gelationsynergywound dressings

Identifiers

PMID40051230
PMCPMC12004432

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.