ArticleObesity (Silver Spring, Md.)2025
Validation of a novel approach to assess metabolic flexibility to a high-fat meal in a whole-body room calorimeter.
Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07613255 (Evaluating Energy Metabolism and Metabolic Health in Individuals With Extreme Obesity), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Energy Metabolism and Metabolic Health in Individuals With Extreme Obesity
Who cites it
2 citing papers in PubMed.
- Whole-Room Indirect Calorimetry in the Study of Obesity, Insulin Resistance and Metabolic Flexibility: A Narrative Review.Nutrients · 2026Review
- Assessing metabolic flexibility in adults under physiological conditions: Effects of dietary fat and exercise in whole-room calorimetry.Physiological reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveMetabolic inflexibility to Western high-fat diets may contribute to the obesity epidemic. However, validated methods for assessing metabolic flexibility (MetFlex) to high-fat meals are currently lacking. The purpose of this study was to evaluate the reliability of a novel approach for determining MetFlex to a high-fat meal and to compare it with the gold standard for measuring MetFlex to high-carbohydrate loads.
methodsEight healthy adults were enrolled in our study, which consisted of the following two assessments of MetFlex: 1) MetFlex to fat, via two overnight stays in a metabolic chamber separated by 5 to 7 days; and 2) Metflex to carbohydrates, via a two-step hyperinsulinemic-euglycemic clamp measured >5 days later.
resultsParticipants were predominantly White and male, with mean (SD) age of 29.4 (6.3) years and BMI of 25.4 (4.1) kg/m
conclusionsOvernight changes in substrate oxidation following a high-fat dinner meal represent a unique aspect of MetFlex that cannot be captured using more conventional methods. Our findings warrant prospective studies to determine whether these parameters are predictive of the development of obesity or metabolic dysfunction.
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Registered trials
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