Gem-Diboronic Acids: A Motif for Anion Recognition in Competitive Media.

Stephen M Butler, Daniel M Beagan, William Lewis, Nathaniel K Szymczak, Katrina A Jolliffe

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Gem-Diboronic Acids: A Motif for Anion Recognition in Competitive Media.Angewandte Chemie (International ed. in English) · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephen M ButlerSchool of Chemistry, University of Sydney, Camperdown, NSW, 2006, Australia.

Daniel M BeaganDepartment of Chemistry, United States Air Force Academy, Air Force Academy, Colorado, 80840, USA.

William LewisSchool of Chemistry, University of Sydney, Camperdown, NSW, 2006, Australia.

Nathaniel K SzymczakDepartment of Chemistry, University of Michigan, 930 N. University, Ann Arbor, MI 48109, USA.

Katrina A JolliffeSchool of Chemistry, University of Sydney, Camperdown, NSW, 2006, Australia.

Funding

The Role of Secondary Interactions Relevant to Biological Reductions of Small MoleculesR35GM136360 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nathaniel Kolnik Szymczak · 2020 to 2026

$2.5M

Australian Research Council CE200100012NIGMS NIH HHS R35 GM136360NIH HHS R35GM136360

6 · The paper itself

Abstract

Gem-diboronic acid derivatives have previously been demonstrated to facilitate substrate binding within a metal's secondary coordination sphere, but their use as an anion recognition motif has not been explored. Here, we introduce the gem-diboronic acid motif as a highly effective group for recognition of oxoanions in aqueous solution. Anion receptors based on this motif demonstrate higher binding affinities than other common neutral motifs such as amides and (thio)ureas, and display a unique selectivity profile. Studies with a receptor bearing two gem-diboronic acid groups, receptor 2, indicate that the interaction with anions is highly directional. Despite its simplicity, receptor 2 represents one of the most selective receptors for malonate reported to date.

Indexed as

Anion receptorAnion recognitionBoronic acid

Identifiers

PMID40051088

DOI10.1002/anie.202502582

PMCPMC12051827

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.