ArticleLipids in health and disease2025
Association of the atherogenic index of plasma with frailty in U.S. adults: a cross-sectional study based on NHANES.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Interpretable machine learning framework for frailty risk prediction using NHANES 2007-2018: A cross-sectional study.Medicine · 2026Article
- Review
- The association of nontraditional lipid parameters with all-cause and cardiovascular mortality: A national cohort study.Medicine · 2026Article
- Predictive value of the atherogenic index of plasma for frailty in older adults.Internal and emergency medicine · 2026Article
- Association between different dimensions of C-reactive protein-triglyceride-glucose index and the incidence of frailty in middle-aged and elderly adults in China: a nationwide prospective cohort study.Lipids in health and disease · 2026Article
- Cumulative atherogenic index of plasma exposure and cardiovascular disease risk: the mediating role of frailty in a Chinese middle-aged and elderly population.Clinical rheumatology · 2025Article
- Association between the cholesterol, high-density lipoprotein, and glucose index and type 2 diabetes mellitus prevalence in US adults: A cross-sectional study based on National Health and Nutrition Examination Survey 2009-2018.The Journal of international medical research · 2025Article
- Association between alpha-1-acid glycoprotein and frailty in US females aged 20-49 years: analysis of NHANES data (2015-2023).Scientific reports · 2025Article
- Association between the geriatric nutritional risk index with the risk of frailty and mortality in the elderly population.Scientific reports · 2025Article
- The relationship between cholesterol, high-density lipoprotein, and glucose index and hypertension: A study based on two national cohorts.Science progressArticle
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Abstract
backgroundFrailty is a multifactorial syndrome associated with adverse health outcomes. The metabolic underpinnings of frailty, particularly lipid metabolism, are not fully understood. Unlike isolated lipid fractions or inflammatory markers, atherogenic index of plasma (AIP) integrates atherogenic lipid profiles and systemic inflammation. However, its association with frailty has not been extensively studied.
methodsSix thousand four hundred participants from the National Health and Nutrition Examination Survey (NHANES) were enrolled. Frailty was calculated with the frailty index (FI), with scores ≥ 0.21 indicating frailty. Logistic regression adjusted for demographic, socioeconomic, and lifestyle factors evaluated the association between AIP and frailty. Restricted cubic splines (RCS) explored nonlinear associations, and subgroup analyses assessed interactions across age, sex, race, poverty income ratio, smoking status, drinking status, and marital status.
resultsThis study demonstrated a strong dose-response relationship between AIP and frailty. After full adjustment, Individuals in quartile 3 and 4 showed higher odds of frailty than those in lowest quartile, with ORs (95% CI) of 1.26(1.01,1.57) and 1.73(1.34,2.23), respectively. Continuous AIP measures also exhibited significant associations (OR: 1.82, 95% CI: 1.34-2.47). RCS analysis showed that AIP exhibited a nonlinear association with the risk of frailty. Subgroup analyses showed the associations were more pronounced in the females. The sensitivity analyses substantiated the stability and strength of the results.
conclusionsOur findings suggest that elevated AIP levels are independently associated with frailty risk, particularly in females, highlighting its potential as a cost-effective biomarker for risk stratification. Future longitudinal studies are needed to validate AIP's predictive utility and uncover the underlying mechanisms.
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