Evidence map›Paper›PMID 40050922›Full record

ArticleDiabetology & metabolic syndrome2025

Association of obesity and LDL subfractions evaluated by body mass index, waist circumference, and diabetes status: the ELSA-Brasil study.

Eugenio G Moraes, Giuliano Generoso, Isabela M Bensenor, Raul D Santos, Itamar S Santos, Alessandra C Goulart, Steven R Jones, Krishnaji R Kulkarni, Michael J Blaha, Peter P Toth and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eugenio G MoraesInstituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Giuliano GenerosoInstituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Isabela M BensenorCenter for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo, Brazil.
Raul D SantosInstituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Itamar S SantosCenter for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo, Brazil.
Alessandra C GoulartCenter for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo, Brazil.
Steven R JonesThe Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
Krishnaji R KulkarniVAP Diagnostics Laboratory, Birmingham, AL, USA.
Michael J BlahaThe Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
Peter P TothThe Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
Paulo A LotufoCenter for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo, Brazil.
Marcio Sommer BittencourtCenter for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo, Brazil. msbittencourt@mail.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-density lipoproteins (LDL) comprise a pool of particles with different densities that may have variable impact on atherogenesis. Studies suggest that obese individuals with elevated body mass index (BMI) and waist circumference (WC) have increased small and dense LDL subfractions (sdLDL-c). It is unclear if diabetes (T2D) and insulin resistance (IR) may modify this association. We included 4,111 (50.4 ± 8.6 years of age, 45.5% men) individuals with neither prior cardiovascular disease nor use of lipid-lowering medications. Total LDL-c and its subfractions (LDL

Indexed as

Body mass indexLow-density lipoprotein subclassesObesityWaist circumference

Identifiers

PMID40050922
PMCPMC11887076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.