Evidence map›Paper›PMID 40050912›Full record

ArticleLipids in health and disease2025

TSH-stimulated hepatocyte exosomes modulate liver-adipose triglyceride accumulation via the TGF-β1/ATGL axis in mice.

Shizhan Ma, Yayun Wang, Shuteng Fan, Wanli Jiang, Mingliang Sun, Mengzhe Jing, Wenkai Bi, Meng Zhou, Dongming Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shizhan MaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
Yayun WangDepartment of Neurology, Qingdao Traditional Chinese Medicine Hospital Affiliated of Qingdao University, Qingdao, Shandong, 266033, China.
Shuteng FanDepartment of Nursing, Taishan Vocational College of Nursing, Taian, Shandong, 271000, China.
Wanli JiangFirst School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Mingliang SunDepartment of Endocrinology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250014, China.
Mengzhe JingDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
Wenkai BiDepartment of Nuclear Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. 704766457@qq.com.
Meng ZhouDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China. zhoumengg@sdfmu.edu.cn.
Dongming WuDepartment of Geriatric Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250014, China. wudongming123@sina.cn.

Funding

National Natural Science Foundation of China 82370788Natural Science Foundation of Shandong Province ZR2022MH121
6 · The paper itself

Abstract

Subclinical hypothyroidism (SCH) contributes to obesity, with the liver acting as a crucial metabolic regulator. Thyroid-stimulating hormone (TSH) affects systemic lipid balance, potentially linking SCH to obesity. While the direct impact of TSH on hepatic lipid metabolism has been extensively documented, its role in modulating lipid dynamics in peripheral organs through liver-mediated pathways remains insufficiently understood. This study identifies TSH-stimulated hepatocyte-derived exosomes (exosomes

Indexed as

Adipose TissueExosomesHepatocytesLipaseLiverThyrotropinTransforming Growth Factor beta1TriglyceridesAcyltransferasesAdipocytesAnimalsDiet, High-FatHypothyroidismLipid MetabolismLipolysisMaleAcyltransferasesLipaseMicroRNAsPNPLA2 protein, mouseTgfb1 protein, mouseThyrotropinTransforming Growth Factor beta1TriglyceridesExosomesLipid metabolismObesityThyrotropin

Identifiers

PMID40050912
PMCPMC11884018

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.