ArticleBMC oral health2025
Antibacterial effect of femtosecond laser against Enterococcus faecalis and Fusobacterium nucleatum biofilms on dentin: an in vitro study.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Detection to Disruption: A Comprehensive Review of Bacterial Biofilms and Therapeutic Advances.Antibiotics (Basel, Switzerland) · 2026Review
- Comparative Efficacy of Sonic, Ultrasonic, and Diode Laser-Activated Irrigation with Combination of NaOCl/EDTA/CHX Solutions AgainstClinical, cosmetic and investigational dentistry · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundRemoving infectious bacteria biofilms from the root canal system is crucial for a successful endodontic treatment. This study investigated the antibacterial effect of femtosecond laser (fs-laser) against Enterococcus faecalis (E. faecalis) and Fusobacterium nucleatum (F. nucleatum) biofilms on dentin.
methodsThe chemical composition of dentin slices from extracted human teeth was analyzed using FTIR and Raman probes. The morphology of fs-laser ablated dentin grooves was evaluated by an optical profiler, and the fs-laser ablation fluence threshold was obtained by a mathematical model. A correlation between dentin chemical composition and ablation threshold was established. The antibacterial effect of different fs-laser irradiation dosages within the safe threshold on E. faecalis and F. nucleatum biofilms was firstly evaluated using the growth curve method. The biofilm removal efficacy on dentin and antimicrobial effect in dentinal tubules was further evaluated by CLSM and SEM analysis. The effect of fs-laser irradiation on the microhardness of dentin surface was also evaluated. The fs-laser irradiation process was observed using a spectrometer.
resultsThe peak intensity of phosphate group showed a positive correlation to the fs-laser dentin ablation fluence threshold in both FTIR and Raman spectroscopy. The safe fluence threshold of 1.8 J/cm
conclusionsFs-laser could effectively remove both E. faecalis and F. nucleatum biofilms on dentin, along with a notable antibacterial effect in dentinal tubules.
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