Evidence map›Paper›PMID 40050757›Full record

ArticleBMC cancer2025

Location based BRAF V600E mutation status and dimension patterns of sporadic thyroid nodules: a population-based study.

Hui Tang, Dan Guo, Bin Yang, Shu-Hua Huang

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Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Hui TangDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China. huitang0905@zju.edu.cn.
Dan GuoNorthern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225000, China.
Bin YangNorthern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225000, China. 992594325@qq.com.
Shu-Hua HuangNorthern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225000, China. 157838242@qq.com.

Funding

the Innovative Talent Support Program of the Department of Health of Zhejiang Province 2020RC056the Natural Science Foundation of Zhejiang Province LY22H090021the Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX21_3288
6 · The paper itself

Abstract

Fine-Needle Aspiration (FNA) has been routinely used for papillary thyroid carcinoma (PTC) diagnosis. One single liquid based tissue sample collected from FNA can be used for both cytological diagnosis and genetic testing at the same time. BRAF V600E mutation exhibits 100% specificity and high sensitivity for papillary thyroid carcinoma (PTC). However, FNA based studies on the genotypic (BRAF V600E) and ultrasonic (US) imaging characteristics (location and diameter) are exceedingly rare. Here, we aimed to study the genotypic (BRAF V600E) and US imaging characteristics (location and diameter) in a large retrospective cohort. A total of 4808 patients with thyroid nodules from a tertiary center underwent FNA, and 2430 patients underwent molecular testing. Our data demonstrated that the thyroid nodules were predominantly located on the right side (p = 0.0004). Patients diagnosed with Bethesda VI cytology had significantly more right-sided thyroid nodules (p = 0.0041). Interestingly, among patients with PTC with lymph node metastasis (LNM), right-side-affected LNM was significantly more common than left-side-affected LNM, which implies a biased regional LNM of right-side-located thyroid nodules (p = 0.0007). The size of BRAF-V600E mutated or right-lobe located nodules was significantly larger than that in the control group (p = 0.0156), and patients with a BRAF V600E mutation were considerably younger than those with wild-type BRAF.

Indexed as

MutationProto-Oncogene Proteins B-rafThyroid NeoplasmsThyroid NoduleAdultAgedBiopsy, Fine-NeedleFemaleHumansLymphatic MetastasisMaleMiddle AgedRetrospective StudiesThyroid Cancer, PapillaryUltrasonographyYoung AdultBRAF protein, humanProto-Oncogene Proteins B-rafBRAFFine needle aspirationLymph node metastasis (LNM)Maximal diameterPapillary thyroid carcinoma (PTC)TERTThyroid nodules

Identifiers

PMID40050757
PMCPMC11884127

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.